ID A0A0D3DF14_BRAOL Unreviewed; 1225 AA.
AC A0A0D3DF14;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=106305740 {ECO:0000313|EnsemblPlants:Bo7g106620.1};
OS Brassica oleracea var. oleracea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo7g106620.1, ECO:0000313|Proteomes:UP000032141};
RN [1] {ECO:0000313|EnsemblPlants:Bo7g106620.1, ECO:0000313|Proteomes:UP000032141}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA Chalhoub B., Sharpe A.G.;
RT "Transcriptome and methylome profiling reveals relics of genome dominance
RT in the mesopolyploid Brassica oleracea.";
RL Genome Biol. 15:R77-R77(2014).
RN [2] {ECO:0000313|EnsemblPlants:Bo7g106620.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR RefSeq; XP_013597559.1; XM_013742105.1.
DR AlphaFoldDB; A0A0D3DF14; -.
DR EnsemblPlants; Bo7g106620.1; Bo7g106620.1; Bo7g106620.
DR GeneID; 106305740; -.
DR Gramene; Bo7g106620.1; Bo7g106620.1; Bo7g106620.
DR KEGG; boe:106305740; -.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR HOGENOM; CLU_001561_0_1_1; -.
DR OMA; WNQEDIC; -.
DR OrthoDB; 1035853at2759; -.
DR Proteomes; UP000032141; Chromosome C7.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF502; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000032141}.
FT DOMAIN 14..179
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1225 AA; 139497 MW; AC1B31D834D5CA0E CRC64;
MAATSSCKSD PSRRQYDVFL SFRGTDTRHS FTCYLLDFLR RKGIDAFIDE ELRRGNDLSA
LLERIEQSKI SIVVFSENYA DSAWCLEELA KIMECKRTFD QVVLPVFYKV PASDVRYQTG
KFGAPFERSE EVFQGSEHRV PAWKEALRAS SDIAGYVLPE RSPECDFVDK IAKETFKVLN
KLSPSEFRGL PGIESRMMEL EKLIDFEETS CVRIVGVLGM AGIGKTTVAD CVYKQNYNRF
DGYCFLANVQ NESKLHGLDH LQRKLLRKLL DEENLDVGAP EGAHKAFKDR LRNKKLFIVL
DDVANENQLR NLIGGAGQEL YREGTRIVIT TSNKKLLEKV VNETYVVPRL SGRESLELFC
LSAFSSNLCA TPELMDLSNK FVDYSKGHPL ALKLLGSDLC QRDKSYWKLK WERLQRRPDG
KIHDVLKVSY EELCEEEQSI FLDVACFFRS EKLDFVSRVL STYHTDASTL ISDLIDKCLI
TVSDNRLEMH DLLLTMGREV GYESSIKEAG NRSRLWNQED ICRVLKYKTG TAETRGIFLD
MSNVDSMKLS ADIFSRMWNL KFLKFYNSHC SKWCENDCRL RFPKGLDCFP DELVYLHWQG
YPLEYLPSNF NPKKLVYLNL RYSNIMQLCE DEKNTGELRW VDLSYSKELM NLTGLLEARK
LERLNLENCT SLTKCSAIRQ MDSLVSLNLR DCINLKSLPK RINLKSLKVV ILSGCSKLKK
FPTISENIES LYLDGTAVKR VPESIESLQK LTVLNLKKCS RLMHLPTTLC KLKSLKELLL
SGCSKLESFP DINEDMESLE ILLMDDTAIK QTPRKMDMSN LKLFSFGGSK VHDLTCLELL
PFSGCSRLSD MYLTDCNLYK LPDSFSCLSL LQTLCLSRNN IKNLPGSIKK LHHLKSLYLK
HCQNLVSLPV LPSNLQYLDA HGCISLETVA KPMTLLVVAE RNQSTFVFTD CFKLNRDAQE
SIVAHTQLKS QILGNGSIQL NHKGLVSEPL ASVSFPGNDL PLWFRHQRMG SSMETHLPPH
WCDDKFIGLS LCVVVSFKDY VDKTNRFSVI CKCKFRNEDG DCVSFTCNLG GWKEQCGSSS
SREEEPRKLT SDHVFISYNN CFHAKKSHDL NRCCNTTASF KFFVTDGVAK RKLDCCEVVK
CGMSLLYAPD ENDCRLQGLQ ESSLEKAISG KVTETAVDEA VVSKRGRFCI PEELLNGKRI
KKEISFTDCD CSVLSYIEPA KPNLC
//
