ID A0A0D3DHU8_BRAOL Unreviewed; 1195 AA.
AC A0A0D3DHU8;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=MutL C-terminal dimerisation domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=106301197 {ECO:0000313|EnsemblPlants:Bo7g117460.1};
OS Brassica oleracea var. oleracea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo7g117460.1, ECO:0000313|Proteomes:UP000032141};
RN [1] {ECO:0000313|EnsemblPlants:Bo7g117460.1, ECO:0000313|Proteomes:UP000032141}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA Chalhoub B., Sharpe A.G.;
RT "Transcriptome and methylome profiling reveals relics of genome dominance
RT in the mesopolyploid Brassica oleracea.";
RL Genome Biol. 15:R77-R77(2014).
RN [2] {ECO:0000313|EnsemblPlants:Bo7g117460.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR RefSeq; XP_013592998.1; XM_013737544.1.
DR AlphaFoldDB; A0A0D3DHU8; -.
DR STRING; 109376.A0A0D3DHU8; -.
DR EnsemblPlants; Bo7g117460.1; Bo7g117460.1; Bo7g117460.
DR GeneID; 106301197; -.
DR Gramene; Bo7g117460.1; Bo7g117460.1; Bo7g117460.
DR KEGG; boe:106301197; -.
DR eggNOG; KOG1977; Eukaryota.
DR HOGENOM; CLU_009113_0_0_1; -.
DR OMA; DHHAVEH; -.
DR OrthoDB; 9570at2759; -.
DR Proteomes; UP000032141; Chromosome C7.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000032141}.
FT DOMAIN 215..347
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 954..1114
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 381..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1195 AA; 133548 MW; 7A0117587EC6C303 CRC64;
MKTIKPLPEG VRRSMRSGII MFDMTRVVEE LVFNSLDAGA TKVSIFVGVV TCSVKVVDDG
SGVSRDDLVL LGERYATSKF HDFIDVETAS ESFGFRGEAL ASISDISLLE ITTKAVGRPN
GYRKVMKGSK CLHLGIDDDR KDSGTTVTVR DLFYNQPVRQ KYMQSSPKKV LESITKCVFR
IALVHSNVSF SVLDIDSDEE LLQANPSASA FSLLMSDAGT EALNSLCKVD VKDGTLNVSG
YISGPRDSFK VLQYIYINSR FVSKGPIHKL LNNFAASFDS TDDWKPTDGL QTGRRSRIQP
CPGYILCITC PRHLYELSFE PSKTNVEFKN WEPILTLIER IILANWKKDE GLEICDGRAD
LLAKGDRQDL IDDMGRLEKD AEWPETMEPT KKKLKRSNDE TPSSFLFPPS ADFKRDDGYL
SEGKEEWSPK YELGMKIQNL KEQDTVAEFD RQTASFLQPC DTDMQKNEDF PQVTGFLETR
LVSGAKCSKQ FLTRCQISTP SVNHDFMEDA DVLNFQFEDV EDELDVSNCI GNHLLRGCSS
RGRLALHEPN LSRGEGSESG MRMKLDDKRT NSLIHVLETR EGDSYRDVLS DTHEFHGRTR
TPDCSLGSSW QESDWFNPQH ISDSTSVGNG EDFNINRIDI AEFRSYEDNF VKKIYSSSAN
VGRSGPGSFR LSSECSTVFS TSPSATEWES DYQKGCQILE GSLDLGRTPD PGYFFSAAND
VKFDHEAIPQ ISCRKTSTDS FADIQNGTES GETIFQSLWG HADNVGIEQH NIRKDTFSYR
YGSKNNVGKR RSRRSRSAPP FYQEKKRFVS LSCRSDTKSK NSDPSVPDDL ECLTQPCNAS
HIFDDVSYDH LQEPEKSMSS ASDLKASAGC SIVHSEARYE DGDEDLSSEE NLDPVKSTTK
WRHNCPVPQV AKESHELHDQ DSVLDICSGL LHLRSDESLV PESINRQSLE DAKVLQQVDK
KYIPIVACGT VAIVDQHAAD ERIRLEELRK KVLAGEARTV TYLSADQELV LPEMGYQLLQ
SYSDQIRDWG WICSINVEGS TSFKKSMSII QRKPTPITLN AVPCVLGVNL SDVDLLEFLQ
QLADTDGSST IPPSVLRVLN SKACRGAIMF GDSLLPSECS LIIEGLKQTS LCFQCAHGRP
TTVPLVDLKA LHKQIAKIEP RQPWHGFERR EITLDRAKSR ADEAKGKKVA PVANL
//
