ID A0A0D3HEN0_9ORYZ Unreviewed; 951 AA.
AC A0A0D3HEN0;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=Non-lysosomal glucosylceramidase {ECO:0000256|PIRNR:PIRNR028944};
DE Short=NLGase {ECO:0000256|PIRNR:PIRNR028944};
DE EC=3.2.1.45 {ECO:0000256|PIRNR:PIRNR028944};
OS Oryza barthii.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=65489 {ECO:0000313|EnsemblPlants:OBART10G13010.2};
RN [1] {ECO:0000313|EnsemblPlants:OBART10G13010.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IRGC 105608 {ECO:0000313|EnsemblPlants:OBART10G13010.2};
RX DOI=10.1007/s12284-009-9025-z;
RA Rounsley S., Marri P.R., Yu Y., He R., Sisneros N., Goicoechea J.L.,
RA Lee S.J., Angelova A., Kudrna D., Luo M., Affourtit J., Desany B.,
RA Knight J., Niazi F., Egholm M., Wing R.A.;
RT "De novo next generation sequencing of plant genomes.";
RL Rice 2:35-43(2009).
RN [2] {ECO:0000313|EnsemblPlants:OBART10G13010.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- FUNCTION: Non-lysosomal glucosylceramidase that catalyzes the
CC hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
CC {ECO:0000256|PIRNR:PIRNR028944}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-
CC acylsphing-4-enine + D-glucose; Xref=Rhea:RHEA:13269,
CC ChEBI:CHEBI:4167, ChEBI:CHEBI:15377, ChEBI:CHEBI:22801,
CC ChEBI:CHEBI:52639; EC=3.2.1.45;
CC Evidence={ECO:0000256|PIRNR:PIRNR028944};
CC -!- SIMILARITY: Belongs to the non-lysosomal glucosylceramidase family.
CC {ECO:0000256|PIRNR:PIRNR028944}.
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DR AlphaFoldDB; A0A0D3HEN0; -.
DR EnsemblPlants; OBART10G13010.2; OBART10G13010.2; OBART10G13010.
DR Gramene; OBART10G13010.2; OBART10G13010.2; OBART10G13010.
DR Proteomes; UP000026960; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR014551; B_Glucosidase_GBA2-typ.
DR InterPro; IPR006775; GH116_catalytic.
DR InterPro; IPR024462; GH116_N.
DR PANTHER; PTHR12654; BILE ACID BETA-GLUCOSIDASE-RELATED; 1.
DR PANTHER; PTHR12654:SF0; NON-LYSOSOMAL GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF04685; DUF608; 1.
DR Pfam; PF12215; Glyco_hydr_116N; 1.
DR PIRSF; PIRSF028944; Beta_gluc_GBA2; 2.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|PIRNR:PIRNR028944};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR028944};
KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR028944};
KW Membrane {ECO:0000256|PIRNR:PIRNR028944};
KW Reference proteome {ECO:0000313|Proteomes:UP000026960}.
FT DOMAIN 102..401
FT /note="Glycosyl-hydrolase family 116 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12215"
FT DOMAIN 537..895
FT /note="Glycosyl-hydrolase family 116 catalytic region"
FT /evidence="ECO:0000259|Pfam:PF04685"
FT REGION 85..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 106648 MW; AF9198E5CBE10B66 CRC64;
MVSGNLFHCR RNSWPAEEYV GRTALQLLDF DGGSPPEQAW RRRLNSHANL LKEFSVTFME
AMRMMSLGLR LWSYVREEAS HGRKAPIDPF TKEKCKPSAS QGVPLGGMGS GSISRGFRGE
FKNWHIIPGL CETSPIFVSR DGGNKKYSSV LSPGHHEGLK KCNDSGISSW DWNLSGQHST
YHALFPRAWT VYDGEPDPDL KISCRQISPF IPHDYKDSSL PTSVFVYTLV NTGKDRAKVS
LLMTWANSIG GFSHHSGGHF NEPFITAKDN PPVTFAIAAC ETQNVNVTVL PVFGLSGEGH
DSAKQMWDRM KQNGHFDREN FEAGTSMPSS SGETLCAAVS ASTWVEPHGR CTVVFGLAWS
SPKIKFQKGC TYNRRYTEFY GTSERSAVNL VHDALTKYRI WEEEIEKWQN PILKNEKLPE
WYKFTLFNEL YFLVAGGTVW TDGQPPVIDG KPSPGSNQQK SSKRGTRDTK QESVKDNHVK
LTAEQVTNGG DLANGEEQSV SKYAAVHGPQ MAKATNGLGS QEPIPYLLSK NGPENVGKFL
YLEGVEYIMW CTYDVHFYAS FALLDLFPKI ELSIQRDFAN AVLYEDRRRM KFLADGTSGI
RKVKGAVPHD LGTHDPWHEM NAYNIHDTSK WKDLNPKFVY RDFAATGDMS FGRDVWPAVC
AAMDYMNQFD RDGDGLIEND GFPDQTYDAW TVHGISAYCG GLWLAALQAA ATMAHRLGDR
PFAEKYKLKF IQAKAVYEAK LWNGSYFNYD SGTSSNSRSI QADQLAGQWY AASSGLPPLF
DENKIRSALQ KIFEFNVMKV KGGRLGAVNG MTPNGKVDET CMQSREIWTG VTYGVAANML
LHGMEHQGFT TAEGIFIAGW SEEGYGYWFQ TPEGWTIDGH YRSLIYMRPL AIWAMQWARS
PPKAILDAPK VNLMDRIHLS PQMIRAMNEI NVRKIAPDNR CFPSSAFRCE C
//