ID A0A0D3LHL1_9BACT Unreviewed; 777 AA.
AC A0A0D3LHL1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Tyrosine-protein kinase {ECO:0000313|EMBL:AHM61596.1};
GN ORFNames=D770_16710 {ECO:0000313|EMBL:AHM61596.1};
OS Flammeovirgaceae bacterium 311.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Flammeovirgaceae.
OX NCBI_TaxID=1257021 {ECO:0000313|EMBL:AHM61596.1, ECO:0000313|Proteomes:UP000064112};
RN [1] {ECO:0000313|EMBL:AHM61596.1, ECO:0000313|Proteomes:UP000064112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=311 {ECO:0000313|EMBL:AHM61596.1,
RC ECO:0000313|Proteomes:UP000064112};
RA Fang C.;
RT "Complete bacteria genome obtained just from illumina data.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; CP004371; AHM61596.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D3LHL1; -.
DR STRING; 1257021.D770_16710; -.
DR KEGG; fbt:D770_16710; -.
DR OrthoDB; 9794577at2; -.
DR Proteomes; UP000064112; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AHM61596.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000064112};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 17..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..96
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 595..749
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 777 AA; 87484 MW; 842401F09A1F5BF7 CRC64;
MEEIDVKIIF RKVLRKWYLF VLSLTLTLGL AFFYLATTQQ VYLVESTIQL KDQSLIDNGA
AHQKFLSGLE LFASDPLLED EIGILSSYAT INQTVERLGM EVSYFRYPAL LGTAGKVFAK
EVYPAPFDVE LDSSAGQLMY TPIHITFPDE QHYRVQISGK DKLQYLYYPL SRGVVSSSST
IELDTVLSVQ QALKTPYLSF SLGYIDASVL ESTNAYYFII SSPDKITENF RKQLKCEQLS
EKSNIVKLSL HSAVPERDVL FLKVLSHVYI ENDLKKKNRL GEKTIEFIDF QLQGVTDSLR
SAETTLEAFR AKSNIIDVER TSHTLSDQLF SLEERQAQLM VQNKYYQYMS DYLARNDDIS
DIVAPSSVGI QDELLNSLLI QLSTLNEEKI GKDFSSSKQN PVMQVLEKKI RNTKQSLIDN
IENLIGSNNI ALQESSRRLA ELKRTISKLP ENERNLTDIK RRFAFNDNIY NYLLQKKAEA
GIAIASNVPN KSVIDAARQI GNAPVGAGSA FVLFIAGLLG LLMPVGFIFV SELFQTKLES
DDQLEKWTDI SLVERIALLK SKELNNRYTG ESYLAHAFRY VRHHIDFLRL NQQVKVVGIS
SAKSGEGKTF CALNLAITFA HAGQKTLLID ADLHHPALAS KLNIDTTSGL GEYLSKEQQP
VISKTDYTGL SFLCAGKPQE NASDLLAHPR LGALMATLRE QYDVIILDAP PVGIVADYLQ
LGKHTDYTFL VVRQDYTQRD ELHRLTKLVK RHSIHCGIIY NGAAGVEEYS GYYKKKV
//
