ID A0A0D3VIM9_9BACL Unreviewed; 3639 AA.
AC A0A0D3VIM9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=UB51_07430 {ECO:0000313|EMBL:AJS61436.1};
OS Paenibacillus sp. IHBB 10380.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1566358 {ECO:0000313|EMBL:AJS61436.1, ECO:0000313|Proteomes:UP000032320};
RN [1] {ECO:0000313|EMBL:AJS61436.1, ECO:0000313|Proteomes:UP000032320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IHBB 10380 {ECO:0000313|EMBL:AJS61436.1,
RC ECO:0000313|Proteomes:UP000032320};
RX PubMed=25908145;
RA Pal M., Swarnkar M.K., Thakur R., Kiran S., Chhibber S., Singh A.K.,
RA Gulati A.;
RT "Complete Genome Sequence of Paenibacillus sp. Strain IHBB 10380 Using
RT PacBio Single-Molecule Real-Time Sequencing Technology.";
RL Genome Announc. 3:0-0(2015).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP010976; AJS61436.1; -; Genomic_DNA.
DR STRING; 1566358.UB51_07430; -.
DR KEGG; pih:UB51_07430; -.
DR PATRIC; fig|1566358.3.peg.1607; -.
DR HOGENOM; CLU_000022_0_13_9; -.
DR Proteomes; UP000032320; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000032320}.
FT DOMAIN 957..1032
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2042..2117
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3085..3159
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3639 AA; 412593 MW; C15A52419A4EE81C CRC64;
MQEGILFHSI VDHNFRGYLV QIGFNINNTI FQIELFEQAF NLVIQKYNIL RSVFVFEEVS
KPLRITAKEK IAQIHYENIA DLEEDERRQY IKEFQKKDRE KGFDLSKDLL MRLSVIQTGK
ETYRVIWSYH HIIMDGWCTG IVLGDLFKYY VQLKSGQRVE LEKAYPYSDY IQWLGEQDQE
EALEYWENYL RGYEQQASVP AQRKGEGNGE YRQEEVIVTV GEKESGQLNR IAQTYQVTIN
TMIQAIWGIL LQRYNQASDV VFGSVVSGRP AEIEGVEKMV GLFVNTIPIR VYAEPEERFA
DLVQGMQHRA LASEKYDYVS LADVQAKSQV KQGLLDHIMV FQNFPIGEEL KNQTDGEGLG
FEIEGVEAFE QTNYDFNITV IPGKQLTFKM NYNAKAHDQE FIRRIGQHLE RIIQQVVKHP
ELRIQELDIV TEEEREQVLV SFNKTEAPYP REKTISELFE EQVEKTPGQV AVVYEGQEWT
YEELNARSNQ VARMLRKHGV GTETIVGIMV ERSLEMMASI LGILKAGGAY LPIDPDYPVE
RIAYMLEDSG TKVLLTQKRL TDRVAFDGSI VALDEAGVYA EEERGNIAGE HTAASLAYVI
YTSGSTGKPK GVLVEHASLT NMLSAMQQRY PLQATGAYLL KTAYTFDVSI TELFGWILGN
GQLVIAKQGA EKDWAKLEEV IDRHSITHIN FVPAMLQLVM NDGVEQEKVR KLEYVFVAGE
ALPSDLANKL NELWPDVSVE NMYGPTEATI YATQYALGKK EGVHVPIGKP LPNTQVYVLS
GANRLQPIGI AGELCIAGDG LARGYLNRPE LTKEKFVENP FVPGERMYRT GDLARWLPDG
NLEYLGRIDE QVKIRGFRIE PDEVRQQLMK HEAVEDAIVV ARKEEEGEAY LCAYVVTEEE
LPVSVWRKHV GESLPEYMIP SYFVRMEHLP LTPNGKVDRK ALPAPEGAVH TGVEYVAPRN
DVEAKLADIW SEVLGMERIG VWDNFFELGG HSLKAMMLVS RIHQELQVEV PLREVFGHAT
IAAITGYLQE AEKKVYTAIE RVEARAFYPV SPAQKRVYVV QQLEGAGVSY NMPTVLKLEG
KLDRGRLGVA LQTVVNRHEA LRTSFDMADG ELVQRVHAEV ELAVSYEEAS VAEMELAVAY
EGASVAEIEP AVSYEEANVA EMELAVVYEE ASVAEIGRLI ETFIRPFDLS QAPLLRAGII
QLGKEEHVLV VDMHHIISDG VSINLFLQEF MQAYEGRELG EPGIQYKDYA VWQQERIRKG
EIEKQEQYWL GAFAGEVPVL ELPTDYPRPA VQQFEGSSVG CELGEEYSQK LVKLSRERGA
TLYMTLLAAY TVLLSKYTGQ EDIVVGTLIA GRGHADLGEV MGMFVNTLAL RNRPEGEKTF
VSYLEDVKAQ VLQAYENQEY PLEELVEKLG VRRDLSRNPL FDTLFALQNM EMKEFGLEGL
KVSPYGYEGK ISKFDVSLQA AEGEGKLYFH VEYGSRLFRQ ETMERWSSHW LRLLEQVADQ
PEIKLSDIEL LTEEEREQVL VSFNKTEAPY PREKTISELF EEQVAKTPKQ VAVVYEGQEW
TYEELNARSN QVARMLRKHG VGSETIVGIM VERSLEMMAG ILGILKAGGA YLPIDPDYPS
ERIAYMLEDS RTKVLLTQKR LQEQLTDRVA FDGSIVALDE AGIYAEEERG NIAREHTAAS
LAYVIYTSGS TGKPKGVLVE HASLTNILSA MQQRYPLQAT GAYLLKTAYT FDVSITELFG
WILGNGQLVI AKQGAEKDWA KLEEVIDRHS ITHINFVPAM LQLVMNDGVE QEKVRKLEYV
FVAGEALPSD LANKLNELWP DVSVENMYGP TEATIYATQY ALGRKEGVHV PIGKPLPNTQ
VYVLDGAKLL QPIGIAGELC IAGDGLARGY LNQPELTEEK FVENPFVPGE RMYRTGDLVR
WLPDGNLEYL GRIDEQVKIR GFRIELGEVR EQLMKHEAVE DAVVVARKGE EGEAYLCAYV
LTEAELPVSS WRKHMGQSLP EYMIPSYFVR MEQLPLTPNG KVDRKALPAP EGAVHTGVEY
VAPRNDTEAK LADIWSEVLG MERIGVWDNF FELGGHSLKA MMLVSRIHQE LQVEVPLREV
FGHATIEAMA GYLQEAEKKS YTPIEQVEAR AYYPVSSAQK RVYVVQQLEG AGVSYNMPTV
LKLEGKLDRG RLGAALQTVV NRHEALRTSF DMADGELVQR VHAEVELAVA YEEASVEEIE
RLIETFIRPF DLSQAPLLRA GIIQLGKEEH VLVVDMHHII SDGGSINLFL QEFMQAYEGR
ELGKRGIQYK DYAVWQQERI RKGDIEKQEQ YWLESFAGEV PVLELPTDYP RPAVQQFEGA
SVGCELGEEY SQKLAKLSLE RGATLYMTLL AAYTVLLSKY TGQEDIVVGT PIAGRGHADL
GEIMGMFVNT LALRNRPKGE KTFVSYLEDV KTQVLQAYEN QEYPLEELVE KLGVRRDLSR
NPLFDTLFAL QNVEMKEFGL KGLKVSPYGY EGKIAKFDVS VQAVEGEGKL YFQMEYGSRL
FRQETMERWS SHWLRLLEQV ADQPEIKLSD IELLTEEERE QVLVSFNETE ALYPREKTIS
ELFEEQAEKT PGQVAVVYEG EEWTYEELNA RSNQVARVLR KHGVGTETIV GIMVERSLEM
MAGILGILKA GGAYLPIDPD YPAERIAYML EDSGTKVLLT QKRLTDRVAA FEGSIVVLDE
VGVYAEEERG NITREHTAAS LAYVIYTSGS TGKPKGVMVE QRNVVRLLFN DKNLFDFGDT
DTWTLFHSFC FDFSVWEMYG ALLYGGKLIV VPQQTVKNPQ QFLQLLKDQQ VTILNQTPMY
FYQLLHEEGR EVGEKLAVRN VIFGGEALSP SILKEWKRKQ PDIRLINMYG TTETTVHVTY
KEITEVEIAQ GKSNIGKPIP TLRAYILDKQ QRIQPIGIQG ELYVAGKGVA RGYLNRPELT
EEKFVENPFV PGERMYRTGD LARWLPDGNL EYLGRIDEQV KIRGFRIELG EVHEQLIKHE
AVEDAVVVAR KGEEGQSYLC AYVVTEEELP VSAWRKHMGE SLPEYMIPSY FVRVEKLPLT
PNGKVDRKAL PAPEGAVHTG VEYVAPRNDV EAKLADIWSE VLGLERIGIR DNFFELGGDS
IKAIQISARL HKQQLKLEIA NLFLHPTIED VSLYVRQVEM SIDQGQVKGQ VELTPIQRWF
FEQDFQAKHH WNQSMMVYRQ EGFNSEALRE ILQELVAHHD ALRMRYEGEG DSVVQVNAGI
EGNEIELSVV EIVGDAEEAA RRIESESERL QSSLNLQSGP LMRGGLFKTS EGDHLLLAVH
HLVIDGVSWR ILFEDLAIGY EQKLANEEVN LPEKTNSYQQ WSKELKEYAN SRKLLKEKPY
WKAVEEAEIA RLPKDEEVEA KGNTWGESRI EIVEFTEEET EKLLRNVHQA YHTEMNDILL
TGLAQAVEEW TGEGRVGLTL EGHGREEVIK GVNVSRTVGW FTSMYPVVLE IKGREELGNQ
IKQVKETLRR IPNKGIGYGI LKYVTEKEKT RDLEFKQRPE ISFNYLGQFD TEMRSGVFEG
SGMPMGSTFH RDSERVHRLD IGGAIMGGKL QMSIQYPGRE YREETIKGLL ESYRDHLRRI
IEHCVQKEDA EMTPSDLKDN ELTFEELEYI LDMTKNVQR
//
