ID A0A0D4DA20_9CAUD Unreviewed; 299 AA.
AC A0A0D4DA20;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=HB2014_82 {ECO:0000313|EMBL:AJT60656.1};
OS Salmonella phage vB_SPuM_SP116.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Ounavirinae; Felixounavirus; Felixounavirus SP116.
OX NCBI_TaxID=1567025 {ECO:0000313|EMBL:AJT60656.1, ECO:0000313|Proteomes:UP000201623};
RN [1] {ECO:0000313|EMBL:AJT60656.1, ECO:0000313|Proteomes:UP000201623}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bao H.;
RT "A new lytic Salmonella pullorum phage and its enzyme lys52.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; KP010413; AJT60656.1; -; Genomic_DNA.
DR RefSeq; YP_009146325.1; NC_027329.1.
DR GeneID; 24725710; -.
DR KEGG; vg:24725710; -.
DR OrthoDB; 13491at10239; -.
DR Proteomes; UP000201623; Genome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..297
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 299 AA; 34101 MW; A0FADEF2E572EA53 CRC64;
MSQADTSYKN ILSHVLSVGE LRTTRTGDVI SAFAPPQFRF DMRTGFPLLT SKQVFTRQVI
GEALWFLNGE NKLGELRYRT WGENDGERWT IWSDDFKRWL SSNYSSEQDW LEDAGGRIYG
VQWRNFEGHN GCVVDQLETL VTKMKGDITD RYMLVNAWNA ADIAANSMAL APCHVLFQIY
ITNEGEVDLQ WYQRSVDTFL GLPFNIASYG FILEVLCKMT GYTPRYLIGV FGDTQIYQNH
MKQVYELMNN EEFHAPTFEI GVPLNTLSDL KHLTASDFIG GINNYQHAGK IEAPLSVGK
//
