ID A0A0D5M0V6_9GAMM Unreviewed; 556 AA.
AC A0A0D5M0V6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:AJY49840.1};
DE EC=1.1.99.1 {ECO:0000313|EMBL:AJY49840.1};
GN ORFNames=KO116_01351 {ECO:0000313|EMBL:AJY49840.1};
OS Halomonas sp. KO116.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=1504981 {ECO:0000313|EMBL:AJY49840.1, ECO:0000313|Proteomes:UP000028645};
RN [1] {ECO:0000313|EMBL:AJY49840.1, ECO:0000313|Proteomes:UP000028645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KO116 {ECO:0000313|EMBL:AJY49840.1,
RC ECO:0000313|Proteomes:UP000028645};
RX PubMed=25953187;
RA O'Dell K.B., Woo H.L., Utturkar S., Klingeman D., Brown S.D., Hazen T.C.;
RT "Genome Sequence of Halomonas sp. Strain KO116, an Ionic Liquid-Tolerant
RT Marine Bacterium Isolated from a Lignin-Enriched Seawater Microcosm.";
RL Genome Announc. 3:0-0(2015).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; CP011052; AJY49840.1; -; Genomic_DNA.
DR RefSeq; WP_035559866.1; NZ_CP011052.1.
DR AlphaFoldDB; A0A0D5M0V6; -.
DR STRING; 1504981.KO116_01351; -.
DR KEGG; hak:KO116_01351; -.
DR eggNOG; COG2303; Bacteria.
DR HOGENOM; CLU_002865_7_1_6; -.
DR OrthoDB; 9785276at2; -.
DR Proteomes; UP000028645; Chromosome.
DR GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000313|EMBL:AJY49840.1}.
FT DOMAIN 276..290
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 233
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 556 AA; 61527 MW; F0EE03A4BB0ADBDD CRC64;
MSEPTNNNFD YIVIGAGTAG CLLANRLSTN PNNKVLLIEA GGRDNYHWIH IPVGYLYCIN
NPRTDWLFRT EPDKGLNGRS LIYPRGKTLG GCSSINGMIY MRGQARDYDH WAEVTGDDAW
RWENCLPDFI KHEDHYRLDE GGDADAKHRN FHGHGGEWRI EKQRLKWQVL DDFAEAAVQA
GIPRTDDFNR GSNEGVAYFE VNQRSGWRWN TAKAFLRPAL KRGNLTLWHS TQVNRLLFEQ
AEALRCTGVE VERGGKTQHA ILTKEGGNAE VVLCAGAIGT PHLLQLSGVG PAETLREHGV
EVVHELPGVG ENLQDHLQIR SIYRITNGKT LNAMASTLWG KAGIGLEYLL KRSGPMSMAP
SQLGAFTRST QDQTHPNIEY HVQPLSLEAF GQPLHPYPAI TASVCNLNPT SRGTVRLKSS
DPRQAPAISP NYLSTPEDRK VAADSLRVTR RIAEQPAFAK YAPEEVKPGV EYQSDDELAR
LAGDIGTTIF HPVGTARMGR EDDAMAVVDA RLRVRGVRGL RVADASIMPT ITSGNTNSPT
LMIAEKAAGW MLAERR
//
