ID A0A0D6A1H9_9LACO Unreviewed; 770 AA.
AC A0A0D6A1H9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=LBAT_0274 {ECO:0000313|EMBL:BAQ56663.1};
OS Lactobacillus acetotolerans.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=1600 {ECO:0000313|EMBL:BAQ56663.1, ECO:0000313|Proteomes:UP000035709};
RN [1] {ECO:0000313|EMBL:BAQ56663.1, ECO:0000313|Proteomes:UP000035709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 13120 {ECO:0000313|EMBL:BAQ56663.1,
RC ECO:0000313|Proteomes:UP000035709};
RA Toh H., Morita H., Fujita N.;
RT "Complete genome sequence of Lactobacillus acetotolerans NBRC 13120.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; AP014808; BAQ56663.1; -; Genomic_DNA.
DR RefSeq; WP_060459151.1; NZ_AP014808.1.
DR AlphaFoldDB; A0A0D6A1H9; -.
DR STRING; 1600.LBAT_0274; -.
DR KEGG; lae:LBAT_0274; -.
DR PATRIC; fig|1600.4.peg.280; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000035709; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000035709}.
FT DOMAIN 17..340
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 770 AA; 90220 MW; FD4AD7E932A0EFB9 CRC64;
MDDLSAISII EEACGYKLSK EQKTCIVNHS KKSTLINACA GSGKTSVMIF SIIFDALTNR
LMPDQVLCMT FSKKAQKEME QRYLELRARI VKMHPSIPVG YWQQPRFNTF EAFFYSRLRR
LSTYSTASVC TDKTKYYQDI IRFIPNNLRN PDVTKKEDLN NIFKMYDLLI SKGYSIDGIS
VNLKNPDVVK LLENKDKKSL STLISAISKY NLDENFTSRY LKAVKRYQEL KAMDNVIDFN
DMKVKLMQAL LGDHKDEIIN SVKRYQEVFI DEFQDIDYLQ WHIIQKLFHK IIHTNLIVVG
DDDQSIYSFR GSNPYFIVNF ADKLVPDAQI FNLSTNYRTD GKILKSSLPM IERNQYRLHK
LIRPNNPASG LCYGDYSTKR GFQDQRFFKK LFFESRNTKK TIAVLVRYNF QKNLIADILT
ESHITYNVAG QIESLQESKV YQVYLRIMTA FFDNDIENYI RSAKWMGFNK FKKFLTEFRK
EYYDNSNDDL ENFLSSSLSM FDTKVLKEEP SSDLLLTLIE ESLEILDYVK LQKKRKDHES
YLVNYFDRIN ELLSDGLNYY CRNHIISKPQ LNVVKDHLTF KMYYYHSFLD FINDEKDRMK
QFNALRHKTS NGRVQLLTIH QAKGMEFDEV FLYGETEDSI ASGWITLNYD FPSNMTYKAF
KAKVDSSLQT YLSLANIMVY CNMPNTGEIF DGFRSKDPTI INDTLRKCYY EIMNISANVE
EERRILYVAM TRAKEMLCIN FAENAPSPLL DEIDQSYVRG MSHLDAKNLI
//
