ID A0A0D6A2W3_9LACO Unreviewed; 785 AA.
AC A0A0D6A2W3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Endonuclease MutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
GN ORFNames=LBAT_0471 {ECO:0000313|EMBL:BAQ56860.1};
OS Lactobacillus acetotolerans.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=1600 {ECO:0000313|EMBL:BAQ56860.1, ECO:0000313|Proteomes:UP000035709};
RN [1] {ECO:0000313|EMBL:BAQ56860.1, ECO:0000313|Proteomes:UP000035709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 13120 {ECO:0000313|EMBL:BAQ56860.1,
RC ECO:0000313|Proteomes:UP000035709};
RA Toh H., Morita H., Fujita N.;
RT "Complete genome sequence of Lactobacillus acetotolerans NBRC 13120.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000256|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00092}.
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DR EMBL; AP014808; BAQ56860.1; -; Genomic_DNA.
DR RefSeq; WP_060459261.1; NZ_AP014808.1.
DR AlphaFoldDB; A0A0D6A2W3; -.
DR STRING; 1600.LBAT_0471; -.
DR KEGG; lae:LBAT_0471; -.
DR PATRIC; fig|1600.4.peg.481; -.
DR OrthoDB; 9808166at2; -.
DR Proteomes; UP000035709; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR046893; MSSS.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR NCBIfam; TIGR01069; mutS2; 1.
DR PANTHER; PTHR48378:SF1; DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48378; DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF20297; MSSS; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF160443; SMR domain-like; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00092};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00092};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00092};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Reference proteome {ECO:0000313|Proteomes:UP000035709}.
FT DOMAIN 710..785
FT /note="Smr"
FT /evidence="ECO:0000259|PROSITE:PS50828"
FT COILED 522..632
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 334..341
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00092"
SQ SEQUENCE 785 AA; 87675 MW; 5535BC67E833F5A3 CRC64;
MNNKILKTLE FGKITHRLSE LAITAPAKKR AEKLVPSNNF DQVKLNLQQT LALANLLRIK
GQLPLTDFND VRPSTKRLSV KANLNAKELG NLLLVLSLAN SVNDFLDDID EEKLNLAAID
SILNELDVPD LLFSELKKSV DYDGTVLDTA SSNLARLRHD MKSNEEDIKN RMDAYIKGNS
SKYLSEQIVT IRDDRYVIPV KQEYRAKFGG VVHDQSASGQ TLFVEPGAVL NLNNRQQNLL
AKERQEVRRV LKHLSNMARE EVTSLNAIAS ALTELDFLQA KAKLAKEMHA SEPKLTKDHS
LNLLKARHPL IDSKKVVPND IRLGSSFDTM LITGPNTGGK TITLKTAGLI QLMAQSGLFI
PAEEGSQVGV FRDICADIGD EQSIEQSLST FSSHINDIIA IMKNVDDQTL VLIDEIGAGT
DPEEGASLAI SILDFLRKKK AKIMITTHYP ELKLYGYNRP RTTNASMEFD LKTLSPTYHL
QIGIPGHSNA FAIARRLGMR EDVVKNAEGL MSDSNSDINK MIERLNKQTK AATDARNHLE
TSLDRSEKLE QKLQRALDWY NQRVQKQLEF AQDRANEVVS KKRKQADRII DQLEKQGTNA
KENKIIDAKG KLNSLERQND NLAHNKVLQR EKRRHHVSVG DRVKVLSYGQ TGTVTKKLSE
HEYEVQLGII KVKVSDRDIE KVSKSSSAGK QKATARTTIA LRRNNVHSEL DLRGQRYNEA
MTNLDRYIDS VLLAGLDTVT IIHGIGTGAI RKGVLKYLRN SNHVKSFNYA PANQGGNGAT
IVQLK
//
