ID A0A0D6A363_9LACO Unreviewed; 466 AA.
AC A0A0D6A363;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=RNA methyltransferase {ECO:0000313|EMBL:QFG51287.1};
DE SubName: Full=tRNA and rRNA cytosine-C5-methylase {ECO:0000313|EMBL:BAQ57252.1};
GN ORFNames=LA749_04470 {ECO:0000313|EMBL:QFG51287.1}, LBAT_0863
GN {ECO:0000313|EMBL:BAQ57252.1};
OS Lactobacillus acetotolerans.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=1600 {ECO:0000313|EMBL:BAQ57252.1, ECO:0000313|Proteomes:UP000035709};
RN [1] {ECO:0000313|EMBL:BAQ57252.1, ECO:0000313|Proteomes:UP000035709}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 13120 {ECO:0000313|EMBL:BAQ57252.1,
RC ECO:0000313|Proteomes:UP000035709};
RA Toh H., Morita H., Fujita N.;
RT "Complete genome sequence of Lactobacillus acetotolerans NBRC 13120.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QFG51287.1, ECO:0000313|Proteomes:UP000325393}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LA749 {ECO:0000313|EMBL:QFG51287.1,
RC ECO:0000313|Proteomes:UP000325393};
RA Kim K.;
RT "Genome sequencing of Lactobacillus acetotolerans.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|ARBA:ARBA00007494,
CC ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; AP014808; BAQ57252.1; -; Genomic_DNA.
DR EMBL; CP044496; QFG51287.1; -; Genomic_DNA.
DR RefSeq; WP_056969643.1; NZ_CP044496.1.
DR STRING; 1600.LBAT_0863; -.
DR GeneID; 78212236; -.
DR KEGG; lae:LBAT_0863; -.
DR PATRIC; fig|1600.4.peg.885; -.
DR OrthoDB; 9810297at2; -.
DR Proteomes; UP000035709; Chromosome.
DR Proteomes; UP000325393; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd21147; RsmF_methylt_CTD1; 1.
DR Gene3D; 2.30.130.60; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018314; Fmu/NOL1/Nop2p_CS.
DR InterPro; IPR031341; Methyltr_RsmF_N.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR027391; Nol1_Nop2_Fmu_2.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR031340; RsmF_methylt_CI.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807:SF30; 28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR Pfam; PF17125; Methyltr_RsmF_N; 1.
DR Pfam; PF13636; Methyltranf_PUA; 1.
DR Pfam; PF17126; RsmF_methylt_CI; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01153; NOL1_NOP2_SUN; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000035709};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 1..297
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 226
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 104..110
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 128
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 173
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 466 AA; 52541 MW; 9DFBE51DDCA61ED3 CRC64;
MLKLPKEFKD KYRKLLGTDE ADEMFTAMND TNKKSFRINP LKFNTKISYS KKAPVPNLAN
AYYGAVSGQD PEWVSGTVYS QDPSAMFPAK VANVQPGERV LDLCAAPGGK STGLGEDLKG
QGVLVANEIS RPRAKVLREN LERWGVSNVL ITSESPEKLA PHFLQFFDKI LVDAPCSGEG
MFRKNPEAIK YWSEDYVLTC QKRQKEILKE AVKMLRPGGE LIYSTCTFSP EEDEQIVAWL
VKNFNLVITP IKSIKMDKIS HGHLDWAQNL DGLQNTLRFW PQDGLGEGQF IAKLTMPGVT
IKAPIKRKNR AKKKLRNKFA LFKDEKELVA AILDKFNLPS ELNDWPKRVL VRKQHVFIPA
LTGKQLDGLK ILSNGLELGI LKKKRFEPGH QLALVLGQVK QERVIDLPNQ ENYQSYLHGE
TVKVDSDLRG FVLISCHNLI FSFGKIANNG VIKNYYPKGL RTLKKG
//
