ID A0A0D6DZ77_9LACT Unreviewed; 380 AA.
AC A0A0D6DZ77;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Bifunctional NAD biosynthesis protein NadR {ECO:0000313|EMBL:CEN29091.1};
GN Name=nadR {ECO:0000313|EMBL:CEN29091.1};
GN ORFNames=LACPI_1891 {ECO:0000313|EMBL:CEN29091.1};
OS Lactococcus piscium MKFS47.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=297352 {ECO:0000313|EMBL:CEN29091.1, ECO:0000313|Proteomes:UP000033166};
RN [1] {ECO:0000313|Proteomes:UP000033166}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MKFS47 {ECO:0000313|Proteomes:UP000033166};
RA Andreevskaya M.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN774769; CEN29091.1; -; Genomic_DNA.
DR RefSeq; WP_047916651.1; NZ_LN774769.1.
DR AlphaFoldDB; A0A0D6DZ77; -.
DR STRING; 1364.LP2241_50247; -.
DR KEGG; lpk:LACPI_1891; -.
DR HOGENOM; CLU_052648_1_1_9; -.
DR Proteomes; UP000033166; Chromosome I.
DR GO; GO:0000309; F:nicotinamide-nucleotide adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0050262; F:ribosylnicotinamide kinase activity; IEA:InterPro.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR016429; NAD_NadR.
DR InterPro; IPR038727; NadR/Ttd14_AAA_dom.
DR InterPro; IPR006417; NadR_NMN_Atrans.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR NCBIfam; TIGR01526; nadR_NMN_Atrans; 1.
DR PANTHER; PTHR37512:SF1; AAA_28 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37512; TRIFUNCTIONAL NAD BIOSYNTHESIS/REGULATOR PROTEIN NADR; 1.
DR Pfam; PF13521; AAA_28; 1.
DR PIRSF; PIRSF004776; NadR_NMNAT/RNK; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR004776-1}.
FT DOMAIN 184..337
FT /note="NadR/Ttd14 AAA"
FT /evidence="ECO:0000259|Pfam:PF13521"
FT BINDING 20..23
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
FT BINDING 27
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
FT BINDING 55
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
FT BINDING 87..100
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
SQ SEQUENCE 380 AA; 43906 MW; 4980C88ADA324371 CRC64;
MQTNNISKGK LSGKKIGVYF GTFAPLHTGH QQQIYKTSAL NEGVLLIVSG YDGDRGSKIG
LHLDKRFRYL REAFNDEAAI KVVKLDENGI PEMPHGWDEW TNRLFGLIQA NTESENLEVT
FYVGEAEYVT ELYKRFPTDD GNTYTVEIAD RHDIQISATM IRENPQTYWQ DINRVFRRQF
SKVVTLMGSA STGKSTLVRR LARSINAPFS EEYARSYEEY SNINDDELEM SDYARLITGQ
YDVNSKEINS PANQGIVFLD TDAIVTRVYA KLYLSEEDQA QLEPLFQKII RDEQMDLILV
IPPITKYIDD GFRNMEWESS RHEFHEELMR QLAEFNLMDK VVLLDDTGDV RDEKGYLSRY
HHAIDAVKQQ TGVEIKRLDY
//
