ID A0A0D6N0I6_9PROT Unreviewed; 929 AA.
AC A0A0D6N0I6; A0A6N3SQ85;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase {ECO:0000313|EMBL:GAN59083.1};
GN ORFNames=Abci_001_099 {ECO:0000313|EMBL:GAN59083.1};
OS Acetobacter cibinongensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Acetobacter.
OX NCBI_TaxID=146475 {ECO:0000313|EMBL:GAN59083.1, ECO:0000313|Proteomes:UP000032671};
RN [1] {ECO:0000313|EMBL:GAN59083.1, ECO:0000313|Proteomes:UP000032671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4H-1 {ECO:0000313|EMBL:GAN59083.1,
RC ECO:0000313|Proteomes:UP000032671};
RA Azuma Y., Higashiura N., Hirakawa H., Matsushita K.;
RT "Whole genome sequence of Acetobacter cibinongensis 4H-1.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-
CC aconitate + H2O; Xref=Rhea:RHEA:17941, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:57429, ChEBI:CHEBI:57872; EC=4.2.1.99;
CC Evidence={ECO:0000256|ARBA:ARBA00000118};
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAN59083.1}.
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DR EMBL; BAMV01000001; GAN59083.1; -; Genomic_DNA.
DR RefSeq; WP_048837179.1; NZ_BJVU01000005.1.
DR AlphaFoldDB; A0A0D6N0I6; -.
DR STRING; 1231339.Abci_001_099; -.
DR Proteomes; UP000032671; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 3.40.1060.10; Aconitase, Domain 2; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR Gene3D; 1.25.40.310; Aconitate B, HEAT-like domain; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR015933; Aconitase_B_HEAT-like_dom.
DR InterPro; IPR036288; Aconitase_B_HEAT-like_dom_sf.
DR InterPro; IPR015929; Aconitase_B_swivel.
DR InterPro; IPR015932; Aconitase_dom2.
DR PANTHER; PTHR43160; ACONITATE HYDRATASE B; 1.
DR PANTHER; PTHR43160:SF4; ACONITATE HYDRATASE B; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF06434; Aconitase_2_N; 1.
DR Pfam; PF11791; Aconitase_B_N; 1.
DR SUPFAM; SSF74778; Aconitase B, N-terminal domain; 1.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 7..162
FT /note="Aconitase B HEAT-like"
FT /evidence="ECO:0000259|Pfam:PF11791"
FT DOMAIN 175..405
FT /note="Aconitase B swivel"
FT /evidence="ECO:0000259|Pfam:PF06434"
FT DOMAIN 411..894
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
SQ SEQUENCE 929 AA; 100530 MW; 1EFC5E4364CB2818 CRC64;
MTAYSDYLID IKERATHGLA PKPIDDGELV RDIITLIEDT GNEQRSDALR FFIYNTLPGT
TSAAGVKADF LKKIVQGAVV VPEITPAYAL ELLSHMKGGP SVRVLLDIAL GTDPAIAKQA
GEVLKTQVFL YDADMFRLRD AYKAGNAVAK DVLESYAKAE FFTKLPDVED AIKVVTFIAA
EGDISTDLLS PGNQAHSRSD RELHGQCMIS PEAQQDIVAL QKQHPDARVM MIAEKGTMGV
GSSRMSGVNN VALWTGKQAS PYVPFVNFAP IVAGTNGISP IFATTVDVTG GIGINLKNWV
RKTGADGKPV LDSDGNPILE QKYSVATGTV LTIDVKNKQL RDENGKELVD IASSFTPQKM
EFMKAGSSYA IVFGKKLQTF AAKTLGIEAP RVFALNKEIT VENQGLTAVE KIFNRNAVGV
TPGKVLHAGS DVRVQVNIVG SQDTTGLMTA QELEAMAATV ISPLVDGAYQ SGCHTASVWD
KKAQANIPKL MKFMNDFGLI TARDPKGVYP PMTDVIHKVL NDLTVSDWDI IIGGDSHTRM
SKGVAFGADS GTVALALATG EATMPIPQSV KVTFKGTMQP HMDFRDVVHA TQAQMLKQCG
DNVFQGRIIE VHIGTLLADQ AFTFTDWTAE MKAKAAICIS QDEALIESLE IAKSRIQIMI
DKGMDNAAGI LKGLIAKADK RIAEIRSGEN PALAPDDNAK YFAEVVVDLD VIDEPMIADP
DVNNPDVSKR YTHDTIRPVS YYGDHKKVDL GFVGSCMVHK GDVKIVAQML KNLEAASGKV
EFGAPLVVAA PTYNIIDELK AEGDWEILER YSGFEFNDQH PKSAARTEYE NILYLERPGC
NLCMGNQEKA EKGDTVLATS TRLFQGRVVE DSSEKKGESL LASTPVVVLS AILGRIPTND
EYKAAVEGIE LTRFAPPKAA LFDPLSVHY
//