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Database: UniProt
Entry: A0A0D6N335_9PROT
LinkDB: A0A0D6N335_9PROT
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ID   A0A0D6N335_9PROT        Unreviewed;       438 AA.
AC   A0A0D6N335;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   13-FEB-2019, entry version 17.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=Abci_011_142 {ECO:0000313|EMBL:GAN60412.1};
OS   Acetobacter cibinongensis 4H-1.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Acetobacter.
OX   NCBI_TaxID=1231339 {ECO:0000313|EMBL:GAN60412.1, ECO:0000313|Proteomes:UP000032671};
RN   [1] {ECO:0000313|EMBL:GAN60412.1, ECO:0000313|Proteomes:UP000032671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4H-1 {ECO:0000313|EMBL:GAN60412.1,
RC   ECO:0000313|Proteomes:UP000032671};
RA   Azuma Y., Higashiura N., Hirakawa H., Matsushita K.;
RT   "Whole genome sequence of Acetobacter cibinongensis 4H-1.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAN60412.1}.
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DR   EMBL; BAMV01000011; GAN60412.1; -; Genomic_DNA.
DR   RefSeq; WP_048838450.1; NZ_BAMV01000011.1.
DR   EnsemblBacteria; GAN60412; GAN60412; Abci_011_142.
DR   OrthoDB; 1464088at2; -.
DR   BioCyc; GCF_000963925:G1EKZ-1380-MONOMER; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000032671; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000032671};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      356    434       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND      15     22       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    212    212       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     112    112       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     197    197       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   438 AA;  45306 MW;  9E531FBD9BAB391C CRC64;
     MSVTPPSSPL RLGIAGLGTV GAGVIRLLET NNDLITARAG RALKVVAVSA RNRTQDRGVT
     LEGLRWYDNA VDLAADPEVD VVVELIGGSE GPARALVEAA LAAGKAVVTA NKALLALHGP
     ALAQSSAANN APLLFEAAVA GGIPAIKTVR EGLAADRLLR IGGILNGTCN YILTVMRETG
     KDFASVLADA QQLGYAEADP STDIDGWDAA HKLAILAGLA FGRPVDFSTV HVQGIRHIGA
     ADLDFARKLG YRIKLLGLAR MGDAGLEARV TPCLVPEDAP IAQVDGVFNA VVAEGAFAGR
     LMIEGRGAGA GPTASAVTAD LIDIARGNTI PVWGVQTTQA EALQACPLSA GKGAFYLRLR
     VEDRPGVIAD ITAVLRDCGV SLRSMLQPTP ARNDTAPYVP LVLVTHQTSE AAMQDAVARI
     DALDVVADAP VVIRIETD
//
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