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Database: UniProt
Entry: A0A0D6XPU5_9STAP
LinkDB: A0A0D6XPU5_9STAP
Original site: A0A0D6XPU5_9STAP 
ID   A0A0D6XPU5_9STAP        Unreviewed;       446 AA.
AC   A0A0D6XPU5;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   13-FEB-2019, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:SUM56376.1};
GN   ORFNames=NCTC13832_00001 {ECO:0000313|EMBL:SUM56376.1}, TP70_05000
GN   {ECO:0000313|EMBL:KIX90839.1};
OS   Staphylococcus microti.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=569857 {ECO:0000313|EMBL:KIX90839.1, ECO:0000313|Proteomes:UP000032366};
RN   [1] {ECO:0000313|EMBL:KIX90839.1, ECO:0000313|Proteomes:UP000032366}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22147 {ECO:0000313|EMBL:KIX90839.1,
RC   ECO:0000313|Proteomes:UP000032366};
RA   Guo J.;
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:SUM56376.1, ECO:0000313|Proteomes:UP000254100}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13832 {ECO:0000313|EMBL:SUM56376.1,
RC   ECO:0000313|Proteomes:UP000254100};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; JXWY01000033; KIX90839.1; -; Genomic_DNA.
DR   EMBL; UHDT01000001; SUM56376.1; -; Genomic_DNA.
DR   RefSeq; WP_044359889.1; NZ_UHDT01000001.1.
DR   EnsemblBacteria; KIX90839; KIX90839; TP70_05000.
DR   PATRIC; fig|569857.6.peg.1312; -.
DR   OrthoDB; 219876at2; -.
DR   BioCyc; GCF_000934465:G1EKJ-1325-MONOMER; -.
DR   Proteomes; UP000032366; Unassembled WGS sequence.
DR   Proteomes; UP000254100; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000032366,
KW   ECO:0000313|Proteomes:UP000254100};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      142    273       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      354    423       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     150    157       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   446 AA;  51055 MW;  AFF50770372F11C2 CRC64;
     MTEQEIWDSV LKLFHEAVTE SSFNTWFKDT KIHSLSNDKI VLVANNPFTA NWLTQNYESM
     IIEYVGAVSG KSITTVNVLT EEDLDELQAD FPTTQNEVKT VDPVTQGEQF NTNNTFDTFV
     IGPGNRFPHA ASLAVAESPA KAYNPLFIYG GVGLGKTHLM HAIGHYVLEN NKDAKVLYTS
     SEKFTNEFIQ SIRNNDTESF REKYRNIDVL LIDDIQFIQK KEQTQEEFFH TFNDLHQNNK
     QIVISSDRPP KEISTLEERL KSRFQWGLIV DITPPDFETR MAILQKKTEE ENLDMPIEAL
     TYIANQIQTN IRELEGALNR VNAYSKLQGK PITTELTADA LKDIIQITKS KKITIQDIQK
     VVGAYYGIRI EDFAAKKRTK SIAYPRQIAM YLSRELTDFS LPKIGEEFGG RDHTTVIHAH
     DKIKKELEND PTLKHEIESL EKEIRS
//
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