ID   A0A0D7A468_9AGAR        Unreviewed;       931 AA.
AC   A0A0D7A468;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Ras GEF {ECO:0000313|EMBL:KIY45603.1};
GN   ORFNames=FISHEDRAFT_76450 {ECO:0000313|EMBL:KIY45603.1};
OS   Fistulina hepatica ATCC 64428.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Fistulinaceae; Fistulina.
OX   NCBI_TaxID=1128425 {ECO:0000313|EMBL:KIY45603.1, ECO:0000313|Proteomes:UP000054144};
RN   [1] {ECO:0000313|EMBL:KIY45603.1, ECO:0000313|Proteomes:UP000054144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 64428 {ECO:0000313|EMBL:KIY45603.1,
RC   ECO:0000313|Proteomes:UP000054144};
RX   PubMed=25683379; DOI=10.1016/j.fgb.2015.02.002;
RA   Floudas D., Held B.W., Riley R., Nagy L.G., Koehler G., Ransdell A.S.,
RA   Younus H., Chow J., Chiniquy J., Lipzen A., Tritt A., Sun H., Haridas S.,
RA   LaButti K., Ohm R.A., Kues U., Blanchette R.A., Grigoriev I.V., Minto R.E.,
RA   Hibbett D.S.;
RT   "Evolution of novel wood decay mechanisms in Agaricales revealed by the
RT   genome sequences of Fistulina hepatica and Cylindrobasidium torrendii.";
RL   Fungal Genet. Biol. 76:78-92(2015).
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DR   EMBL; KN882047; KIY45603.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D7A468; -.
DR   OrthoDB; 5473909at2759; -.
DR   Proteomes; UP000054144; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF312; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054144}.
FT   DOMAIN          449..580
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          628..878
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          257..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          366..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          910..931
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   931 AA;  103151 MW;  E2730C9F5C446000 CRC64;
     MALSSKSSDD SLNSVSSYAT ASSALSPRYP LSLLSEYFDQ SDASSSAGSQ TLTTSSHASK
     LLCPSGFLHL VERRCALGPV LDDANAPVEE KTRAVKCFSD AVISALHTFL ENKRKSEGVA
     TAVNFDPDFD DEDSNGCIGV DSKRLPSCIS VASQEAVVYK IGKGLYDMHM SVSQLLMRVE
     AGYPLEDVLQ WLDSTLQQVI DAGETYCSTL PQSRPNMLVR KATRPQSCKF VERMKTADSP
     ATQASLYSQA SCEISSSDKV NAPLPPVQPP KPFPEHMRKE ISLSHPHEQS QARWKHMSST
     AAAILKTPLE ASSATTSRAA SPTPSTTTSG TQLVAASPAS LQTITAASAP HTPRLRRMSA
     MSNLKHRPPT PIPSVPQVPP VPSQYRAGSP AVTKCRPTSS EVTYQPTDSI KSNISVRSFE
     GVRSTLRESM ALSAEDLANS YTALADSTRK ELPANMELAD LVDTIVDAHL VSEHESLGTD
     CVAQFLLTFR TFATPNVVFN LLAARFARHP LHKADLARAG VLRVMLQWLE LFWVFEWDNQ
     ALGDLRQFCD GPLNRALAEP KGCVDPAEAA RLRSLLGRRH QVRGFRVQRL PPPLSSPISD
     VHAMEMADAL MANKDAKWDG YGKLSDSQKL ELAQHLTVVA HERISQMMRD PMTMLCLAHD
     DLEFAGAKDS LQQYFGFQRG LMLQVMASII SENNTKKRAA IMGAWIDIAK LCEELRNFDC
     MFFIVTALNH HSIWRLKFTQ LLSRQMQKLT ITQKENYRDV NELIKDGAIS TYWRLKDRDT
     PDDAKLPTVP LLAAVPAILV RAGESVCLVK DLINWKSAQR LAEVHDEMRR CYDTPYKFPP
     CSLAIRKTVQ HLVTPIRRED EEVLMGFYES QSIIKEPEDS LLRLTQATGR VPGNFNAYLR
     VPVGRLNKYK TLPLPDSRPL NRRRQTSAEA R
//