ID   A0A0D7AD45_9AGAR        Unreviewed;       502 AA.
AC   A0A0D7AD45;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Histone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein {ECO:0000259|SMART:SM01287};
GN   ORFNames=FISHEDRAFT_73585 {ECO:0000313|EMBL:KIY48615.1};
OS   Fistulina hepatica ATCC 64428.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Fistulinaceae; Fistulina.
OX   NCBI_TaxID=1128425 {ECO:0000313|EMBL:KIY48615.1, ECO:0000313|Proteomes:UP000054144};
RN   [1] {ECO:0000313|EMBL:KIY48615.1, ECO:0000313|Proteomes:UP000054144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 64428 {ECO:0000313|EMBL:KIY48615.1,
RC   ECO:0000313|Proteomes:UP000054144};
RX   PubMed=25683379; DOI=10.1016/j.fgb.2015.02.002;
RA   Floudas D., Held B.W., Riley R., Nagy L.G., Koehler G., Ransdell A.S.,
RA   Younus H., Chow J., Chiniquy J., Lipzen A., Tritt A., Sun H., Haridas S.,
RA   LaButti K., Ohm R.A., Kues U., Blanchette R.A., Grigoriev I.V., Minto R.E.,
RA   Hibbett D.S.;
RT   "Evolution of novel wood decay mechanisms in Agaricales revealed by the
RT   genome sequences of Fistulina hepatica and Cylindrobasidium torrendii.";
RL   Fungal Genet. Biol. 76:78-92(2015).
CC   -!- FUNCTION: Component of the FACT complex, a general chromatin factor
CC       that acts to reorganize nucleosomes. The FACT complex is involved in
CC       multiple processes that require DNA as a template such as mRNA
CC       elongation, DNA replication and DNA repair. During transcription
CC       elongation the FACT complex acts as a histone chaperone that both
CC       destabilizes and restores nucleosomal structure. It facilitates the
CC       passage of RNA polymerase II and transcription by promoting the
CC       dissociation of one histone H2A-H2B dimer from the nucleosome, then
CC       subsequently promotes the reestablishment of the nucleosome following
CC       the passage of RNA polymerase II. {ECO:0000256|ARBA:ARBA00025370}.
CC   -!- SIMILARITY: Belongs to the RTT106 family.
CC       {ECO:0000256|ARBA:ARBA00006159}.
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DR   EMBL; KN881832; KIY48615.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D7AD45; -.
DR   OrthoDB; 1660359at2759; -.
DR   Proteomes; UP000054144; Unassembled WGS sequence.
DR   Gene3D; 2.30.29.120; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR013719; RTT106/SPT16-like_middle_dom.
DR   PANTHER; PTHR45849; FACT COMPLEX SUBUNIT SSRP1; 1.
DR   PANTHER; PTHR45849:SF3; HISTONE CHAPERONE RTT106; 1.
DR   Pfam; PF08512; Rttp106-like_middle; 1.
DR   SMART; SM01287; Rtt106; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054144}.
FT   DOMAIN          258..359
FT                   /note="Histone chaperone RTT106/FACT complex subunit SPT16-
FT                   like middle"
FT                   /evidence="ECO:0000259|SMART:SM01287"
FT   REGION          360..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..418
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..435
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..459
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   502 AA;  54198 MW;  900845F41960F7BC CRC64;
     MSLSTSKTPI INAIAPLLPN EMASGLAELT TNSPQAVFFE TFIRFVTGGD RDASTSISSS
     VWTQKQGPVI NTINSLTRPA KRTRENDDEN NEELGTKRAR TAHDVQDDKV LFTLHSISAT
     CPIRKKVHIL VCENSVRMIN PSSKAVEAVI SRDSITRSFL LPTRNKTKAH WTVVLLSSDA
     GKSAAEQVIF GVDAVAASTT KVTEGGDAEL PISKGQDMHP ILKSFLRHVG APIHQPTSRV
     FKSACPTHVG ISADAGGIPG VEAYRAAKAG TLWFMEEGVL WGESKPCEFW SVQDLHSRSD
     GVRLISATGR TCTVIFKRHA AVENDEDADA GEETEFSMVD GREQQSINNW VMQYRDSFGG
     EKSKGKVGQD RHAARALPSG PITIHQLVAE SDSEDDDFTD SDARSGSVVS SLGGSDSDEE
     SGSDGDDGEE SAAETDDEIM AQREDEKLDP RHHPLLREGA MPRMSKGLVE AVVAMVENDF
     DGGPASVSEG EDGMEEVDEL DD
//