ID A0A0D7AI96_9AGAR Unreviewed; 1039 AA.
AC A0A0D7AI96;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN ORFNames=FISHEDRAFT_38969 {ECO:0000313|EMBL:KIY50568.1};
OS Fistulina hepatica ATCC 64428.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Fistulinaceae; Fistulina.
OX NCBI_TaxID=1128425 {ECO:0000313|EMBL:KIY50568.1, ECO:0000313|Proteomes:UP000054144};
RN [1] {ECO:0000313|EMBL:KIY50568.1, ECO:0000313|Proteomes:UP000054144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 64428 {ECO:0000313|EMBL:KIY50568.1,
RC ECO:0000313|Proteomes:UP000054144};
RX PubMed=25683379; DOI=10.1016/j.fgb.2015.02.002;
RA Floudas D., Held B.W., Riley R., Nagy L.G., Koehler G., Ransdell A.S.,
RA Younus H., Chow J., Chiniquy J., Lipzen A., Tritt A., Sun H., Haridas S.,
RA LaButti K., Ohm R.A., Kues U., Blanchette R.A., Grigoriev I.V., Minto R.E.,
RA Hibbett D.S.;
RT "Evolution of novel wood decay mechanisms in Agaricales revealed by the
RT genome sequences of Fistulina hepatica and Cylindrobasidium torrendii.";
RL Fungal Genet. Biol. 76:78-92(2015).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR EMBL; KN881675; KIY50568.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D7AI96; -.
DR OrthoDB; 151732at2759; -.
DR Proteomes; UP000054144; Unassembled WGS sequence.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 1.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 1.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000054144};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 8..331
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 811..944
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 867..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1039 AA; 110637 MW; 44BC752935FF7DAC CRC64;
MVLIAQSSAG GVLALLSEPD AVFKHHAIKA LNPLVVQFWA EISEHITQIE SLYEDTSLPA
EARDLAALLA SKVYYFLGEY DDALYFALCA GSAFDIDLKS DANRIPGIDE YAETVISKAL
DRYIEQRSQP EAEDAAVDPK LQSIVERIFQ RSINDGDYKQ AHANPAIGIA LDSHRLDIVR
RIYERTDDAS LLSYAMSAVT NTAFSLSYRD RVLNYLFTLY PRPGSSSSYP HVHALTRLLV
TLANPSLTVN FLSSLIPDTS NGAPSSSTAV KLAYQFAFDL VQSGAPDFLS SVLRQLPEGT
ADTKPTHDRI REILSGRKSV KLNLAFLRRN NHVDPLVLKH TKDALDARSS IYHTALTLQN
AFTHAGTTSD VFLRENLEWL GLAANWAKFS ATAALGVIHK GFFEQGQTIL APYLPATNPP
AAPVPGAAYS EGGALYALGL INAGIIPATS GSSPGSTSEA VTYLRSALRA AGENAPIGQD
SEAAQHSVEV VQHGAALGLG IAAMGTRDLE TFELLKDVLF TDSAVAGETA GIAMGLVMLG
AGMAAGELVE GSVKEMLVYA HETRHEKIIR GLALGVAFIF YGRQEESDWV VSTLIVDKDP
ILRYGGVYAL ALAYAGTANN NAVRKLLHVA VSDTSDDVRR AAVTALAFLL FKSPQQVPRI
VQLLSESYNP HVRCGATLAL GLACAGTGLA DAVAILEPMT RDSVDFVRQG AFIALGMVLV
QQADGTGGAG SASGVRALYA KVVADKHEDP MARFGAALGQ GLIDAAGRNA TISLGTGLGA
NRSAIVGMTL FCQFWYWYPL AHCACLAFTP TGIIGLNSDL KIPKFDFVSN ARPSMFAYPA
PTKPPTKATV SKVATAVLST TAKVKAREKR KAAAEGEDDA MDTDKKDDGD IDMKPAKPTA
GDISPIAGSS EPSFEVLPNF SRVTPAQLTY ISFPADGRYQ PVRPVSLSPK HLRSLGLSSE
GPVVGGGILI LDDRYPDQPE EFIELQETPP VSAASVPGAA APAITVPASQ GPDNQRHMDI
GDGPEADLPP PFEYPFGND
//
