ID A0A0D7BMR2_9AGAR Unreviewed; 549 AA.
AC A0A0D7BMR2;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Calcium/proton exchanger {ECO:0000313|EMBL:KIY70881.1};
GN ORFNames=CYLTODRAFT_391457 {ECO:0000313|EMBL:KIY70881.1};
OS Cylindrobasidium torrendii FP15055 ss-10.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Physalacriaceae;
OC Cylindrobasidium.
OX NCBI_TaxID=1314674 {ECO:0000313|EMBL:KIY70881.1, ECO:0000313|Proteomes:UP000054007};
RN [1] {ECO:0000313|EMBL:KIY70881.1, ECO:0000313|Proteomes:UP000054007}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FP15055 ss-10 {ECO:0000313|EMBL:KIY70881.1,
RC ECO:0000313|Proteomes:UP000054007};
RX PubMed=25683379; DOI=10.1016/j.fgb.2015.02.002;
RA Floudas D., Held B.W., Riley R., Nagy L.G., Koehler G., Ransdell A.S.,
RA Younus H., Chow J., Chiniquy J., Lipzen A., Tritt A., Sun H., Haridas S.,
RA LaButti K., Ohm R.A., Kues U., Blanchette R.A., Grigoriev I.V., Minto R.E.,
RA Hibbett D.S.;
RT "Evolution of novel wood decay mechanisms in Agaricales revealed by the
RT genome sequences of Fistulina hepatica and Cylindrobasidium torrendii.";
RL Fungal Genet. Biol. 76:78-92(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
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DR EMBL; KN880462; KIY70881.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D7BMR2; -.
DR STRING; 1314674.A0A0D7BMR2; -.
DR OrthoDB; 276371at2759; -.
DR Proteomes; UP000054007; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProt.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR PANTHER; PTHR31503:SF102; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054007};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 67..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..249
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 391..533
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 261..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 59668 MW; 83EAD0043E133852 CRC64;
MEDNHHDRSD MTSTLRTASL APTALPTKVV RPPPFSRRLT RSLFIRDANT RGPAPNFRAS
IKSAATYSWI NVLLVFNPIA WALHYTHQVD GAIFAVSLLG IVPLAGLLGH GTETIALYTG
DALGGLINAS LGNATEFIIA ILLLVKCEIR VVQASLLGGL LSNLLLVTGM AFLVGGIRFS
EQEFQQSAAQ LNTSLLTLAV IALVLPTVFA FAYDQSNGED KERDIVLEMS RGSAIILIVI
YLSYMVFQLY SHSHLYNPEN DVLRDTPRMS RTSTHSSRSS RRSARSCSPV RRSGQMIAAP
ALSPVRPMPL PQRPSIHPCG PLAFGSAAQL GLGARLRLAT PLRVPQDAES APFEKRFQRP
TVRDELDVAS LNEHDNILEK ETPKMNLTTA ISMLVGTTAL TYLTAEALTD SLEGIGESGA
VSKEWLGLIL LAIVGNAAEH VTAVFVAYRN KVDLALAVSV GSCIQIALFV IPLLVLIGWI
IGKPLSLLFD PLEVVTLFLS VLLVRFATED GRTHYMSGIL LFGSYVLIAF SFWYYPHEGT
TTGNLFAEC
//
