ID A0A0D7CQR5_9ACTN Unreviewed; 729 AA.
AC A0A0D7CQR5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Acyl-CoA dehydrogenase {ECO:0000313|EMBL:KIZ18589.1};
GN ORFNames=SNA_08305 {ECO:0000313|EMBL:KIZ18589.1};
OS Streptomyces natalensis ATCC 27448.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1240678 {ECO:0000313|EMBL:KIZ18589.1, ECO:0000313|Proteomes:UP000032458};
RN [1] {ECO:0000313|EMBL:KIZ18589.1, ECO:0000313|Proteomes:UP000032458}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27448 {ECO:0000313|EMBL:KIZ18589.1,
RC ECO:0000313|Proteomes:UP000032458};
RA Mendes M.V., Beites T., Pires S., Santos C.L., Moradas-Ferreira P.;
RT "Draft genome sequence of Streptomyces natalensis ATCC 27448, producer of
RT the antifungal pimaricin.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009347}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIZ18589.1}.
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DR EMBL; JRKI01000009; KIZ18589.1; -; Genomic_DNA.
DR RefSeq; WP_044363967.1; NZ_JRKI01000009.1.
DR AlphaFoldDB; A0A0D7CQR5; -.
DR PATRIC; fig|1240678.4.peg.1740; -.
DR Proteomes; UP000032458; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR CDD; cd00567; ACAD; 1.
DR Gene3D; 1.10.540.10; Acyl-CoA dehydrogenase/oxidase, N-terminal domain; 2.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 2.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 2.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR013786; AcylCoA_DH/ox_N.
DR InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR PANTHER; PTHR43292; ACYL-COA DEHYDROGENASE; 1.
DR PANTHER; PTHR43292:SF4; ACYL-COA DEHYDROGENASE FADE34; 1.
DR Pfam; PF00441; Acyl-CoA_dh_1; 2.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR Pfam; PF02771; Acyl-CoA_dh_N; 2.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 2.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630}.
FT DOMAIN 6..105
FT /note="Acyl-CoA dehydrogenase/oxidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02771"
FT DOMAIN 218..350
FT /note="Acyl-CoA dehydrogenase/oxidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00441"
FT DOMAIN 383..463
FT /note="Acyl-CoA dehydrogenase/oxidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02771"
FT DOMAIN 467..564
FT /note="Acyl-CoA oxidase/dehydrogenase middle"
FT /evidence="ECO:0000259|Pfam:PF02770"
FT DOMAIN 577..717
FT /note="Acyl-CoA dehydrogenase/oxidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00441"
SQ SEQUENCE 729 AA; 76720 MW; 774B0008FD8E0F93 CRC64;
MGIGITQEHR DLAEATRGWA ARAVPPEEIR TLLDAPPQRH GRPAHWDRLA AQGLLGPHLP
EADGGGGGAL LDLAVVLEEM GRAALPGPYL PTTLAAELLR RAGHRDLVRA LATGELLAAV
ALGTGSLTAV QEADGYILDG TAPPVLAGGD ADVIVLAATA PTGPVWLAAD AATLTVRVQE
SADPTRPVAE VSADGVLVPA ARLLAVDGAL VRDLAGVLFA AESCGTAGRA LETAAEHAAV
REQFGRPIGQ FQAVKHLCAD MLVRCEQARA LVWDAARALD EPPAVRGLVA ALATATALDA
AHTCAKDCIQ ILGGIGFTWE HDAHLHLRRA TVARQLLGSG DSHRLRAARH ATGGARRALR
LDLPAEAAAH RTQARTVIDA ARGLDPAAAR RALAPTGYAA PHLPEPYGLG AGPVRQLAVQ
QELREAGVEI SDLGIATWVI PSLIAHGTKE QQDRYLPPSL RGDLLWCQLF SEPEAGSDLA
SLRTRAERVD GPGGGWRING QKVWTSAAQW ADHGILLART NPDAPRHKGL TFFLVDMKTP
GIDIRPLKEI TGDALFNEVY FDDVLLPADA VVGEIDNGWK VARTTLDNER VHMADQLTFD
TGLEALLERS ADLDGSVRAR VGALAAEAHA LGCIGLRTTL QQVSGLEPGA GAAVRKLVQT
PHQQKVAELA LELLGPAGAV REGAGERALH GFLMSRCLTI AGGTTQVQLN VVAERLLGLP
RDPEPRPLI
//
