ID A0A0D7K7C9_9BURK Unreviewed; 334 AA.
AC A0A0D7K7C9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=BDD18_2764 {ECO:0000313|EMBL:TQN04057.1}, RP29_13935
GN {ECO:0000313|EMBL:KJA09904.1};
OS Acidovorax temperans.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Acidovorax.
OX NCBI_TaxID=80878 {ECO:0000313|EMBL:KJA09904.1, ECO:0000313|Proteomes:UP000032566};
RN [1] {ECO:0000313|EMBL:KJA09904.1, ECO:0000313|Proteomes:UP000032566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KY4 {ECO:0000313|EMBL:KJA09904.1,
RC ECO:0000313|Proteomes:UP000032566};
RA Sheng K.-Y., Chin P.-S., Chan K.-G., Tan G.S.;
RT "Isolation of bacteria from lake water.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TQN04057.1, ECO:0000313|Proteomes:UP000316993}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7270 {ECO:0000313|EMBL:TQN04057.1,
RC ECO:0000313|Proteomes:UP000316993};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJA09904.1}.
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DR EMBL; JXYQ01000046; KJA09904.1; -; Genomic_DNA.
DR EMBL; VFPV01000002; TQN04057.1; -; Genomic_DNA.
DR RefSeq; WP_044399571.1; NZ_VFPV01000002.1.
DR AlphaFoldDB; A0A0D7K7C9; -.
DR STRING; 80878.RP29_13935; -.
DR PATRIC; fig|80878.5.peg.2572; -.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000032566; Unassembled WGS sequence.
DR Proteomes; UP000316993; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF03444; HrcA_DNA-bdg; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000032566};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 4..73
FT /note="Winged helix-turn-helix transcription repressor HrcA
FT DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF03444"
FT DOMAIN 98..316
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 334 AA; 36836 MW; 31E600D4CAD4F0CB CRC64;
MLDDRAKLLL KALVERYIAD GQPVGSRTLS RASGLDLSPA TIRNVMADLE ELGLIASPHT
SAGRVPTARG YRLFVDTMLT VQRDGLEAPQ LMPEQPQKVI ANAAHLLSSL SQFVGVVMAP
RRSSVFRHIE FLRLSERRFL VIIVSPEGDV QNRVIFTDSD YSQSQLVEAA NFLNAHYAGL
EMEQVRERLK SEVDLLRGEI ASLMQAAVNV SSEALSQAQD EVVISGERNL LSVSDFSSDM
GNLRRAFDLF EQKTQILRLL DISSQAEGVR IYIGGESQVV PFEELSVVSA PYEVDGKVVG
TLGVIGPTRM PYDKMIQIVD ITSKLVSNAL SYRK
//
