ID A0A0D7PAS6_9BRAD Unreviewed; 1158 AA.
AC A0A0D7PAS6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=UP09_09570 {ECO:0000313|EMBL:KJC47415.1};
OS Bradyrhizobium sp. LTSP885.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Bradyrhizobium.
OX NCBI_TaxID=1619232 {ECO:0000313|EMBL:KJC47415.1, ECO:0000313|Proteomes:UP000032343};
RN [1] {ECO:0000313|Proteomes:UP000032343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LTSP885 {ECO:0000313|Proteomes:UP000032343};
RX PubMed=25909973; DOI=10.1038/ismej.2015.54;
RA VanInsberghe D.S., Maas K.R., Cardenas E., Strachan C.R., Hallam S.J.,
RA Mohn W.;
RT "Non-symbiotic Bradyrhizobium ecotypes dominate North American forest
RT soils.";
RL ISME J. 9:2435-2441(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJC47415.1}.
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DR EMBL; JYMT01000015; KJC47415.1; -; Genomic_DNA.
DR RefSeq; WP_044537896.1; NZ_JYMT01000015.1.
DR AlphaFoldDB; A0A0D7PAS6; -.
DR STRING; 1619232.UP09_09570; -.
DR PATRIC; fig|1619232.5.peg.709; -.
DR Proteomes; UP000032343; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000032343}.
FT DOMAIN 9..491
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 515..797
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 956..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1158 AA; 127053 MW; 92D75B1007693F94 CRC64;
MVKAIRPIPP AVRDAQARAS DPKASTFVSA NAGSGKTHVL VQRVIRLLLD GVPPEKILCI
TFTKAAAANM AERVFTTLGH WVTLDDAALD DAIRDAGIAH PNPKLRRDAR KLFACALETP
GGLKVQTIHA LCTRLLQQFP FEANVPARFA VLDDRDQNEM MERANLAVFL DAARNPDSPI
GRALMTAMAN AADVTFKDVV REACLSRDHF MAWTDAAGSA AAAAAQMSAA LGVEPDDRIE
DVEREIVDGP NLPRSGWKET ASILDTSTKA DQKQADRLRS ALTFTGAAQV EEYLGVFLTD
DRAPRASVVT NNFIKKNPVA GRRFESEVDR LGPLIERRRA MVACDRTEAL IYIATAAAAN
YRREKLERGL LDYDDLIDKT LDMLDRVSSG WVHYKLDRGV DHVLIDEAQD TSPRQWDIVA
HIISEFTSGA GARDGLMRTV FAVGDEKQSI FSFQGAAPRE FDLRRRELQR RFEDAGLKFD
PVSFTYSFRS GPTILHSVDN VFREQEIFRS IHAVENGYPI HNAMADAGPS LIELWDLAVA
DDRQDIEGWR APFDGVAMTS PEVKLAKRIQ AEIRRLVESG TMTGSEGARR PLRYGDMLIL
VRRRGNAFDA VIQALKHAGV PVAGADRLKL TEHIAIIDLM NLADALLLPQ DDLALAVALK
SPLFGLTDDD LFKLAWQRRG SLRDALAKHA PTDDRFSAVL QRLEQCERRF ADETPFAFYA
WLLGGDGGRA RILRRLGHEA NDALDEFLEL ALNYERKAPA SLQGFVAWLR AADTEVKRDM
EISRDEVRVM TVHGAKGLES AVVFLVDTTT SPSDTQRLRL IHLPQGNAAP HAPGVVVWAG
KKAEDPPSVA DARKAMLGDT EDEYRRLLYV AMTRAADRLI VGGCLPGNMN SVRKSSWYDL
ITKGLANSGL KLEELETPAG KVMRYSRPED VTDATGAAAA AAPVTSALPP WLRASATPEA
STPGLLRPSD PADHDGHQVR TGESILLRAR ALQRGTLVHR LLQSLPDVAA ERRQDAALAY
LARNADSWSD EERAALAAQV LGLIDDPRFA PVFAPGSRPE VSIVGRLERP GQPKALVSGQ
IDRLVVTPGE VLIVDFKTNH TPPKTAAEAP RGHVRQLALY RAVLSKLYPQ RPVRAALLWT
ETPEMMEISA PALDAGLA
//
