ID A0A0D7VXK5_9FLAO Unreviewed; 1047 AA.
AC A0A0D7VXK5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=PK35_16175 {ECO:0000313|EMBL:KJD31178.1};
OS Tamlana nanhaiensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Tamlana.
OX NCBI_TaxID=1382798 {ECO:0000313|EMBL:KJD31178.1, ECO:0000313|Proteomes:UP000032361};
RN [1] {ECO:0000313|EMBL:KJD31178.1, ECO:0000313|Proteomes:UP000032361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FHC16 {ECO:0000313|EMBL:KJD31178.1,
RC ECO:0000313|Proteomes:UP000032361};
RX PubMed=25735434; DOI=10.1007/s10482-015-0410-x;
RA Liu X., Lai Q., Du Y., Li G., Sun F., Shao Z.;
RT "Tamlana nanhaiensis sp. nov., isolated from surface seawater collected
RT from the South China Sea.";
RL Antonie Van Leeuwenhoek 107:1189-1196(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJD31178.1}.
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DR EMBL; JTDV01000017; KJD31178.1; -; Genomic_DNA.
DR RefSeq; WP_044627622.1; NZ_JTDV01000017.1.
DR AlphaFoldDB; A0A0D7VXK5; -.
DR STRING; 1382798.PK35_16175; -.
DR PATRIC; fig|1382798.3.peg.1802; -.
DR OrthoDB; 9801077at2; -.
DR Proteomes; UP000032361; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000032361};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1047
FT /note="beta-galactosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002325075"
FT DOMAIN 766..1043
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1047 AA; 120092 MW; 04ABEAA6BAD30B52 CRC64;
MRLKSQITAI LLAITASTFA QNTPFWLNEK KNEDNRLPMH ASYLVFENEA VAETDDYTQS
KNYINLNGTW KFKYVESPSA IPDGFETTSY NDSQWDNFKI PANWDVNGYG YPVYTNTTYD
FANLIEVNPP NVPTEYNPVG IYRRVFNFDG NTKTNDVLLH VGAAKSNLTV WINGQYVGYG
EDGKLPQEFL LNPYLKEGEN SIVLKVMKWS DGSYLECQDF WRMSGITRDT YVYSRNKTHL
VDFEITPDLD ENYQDATLKV STEIKGFSKK SKYTLDVVLK DEDQVIGSKS FSINANTIKN
TLEFSVSNPK KWTAETPNLY QVHFILKDKK DQVVEVIKTQ TGFRKIEIKG GQLLVNGQPI
YIKGVNRHET DPTTGQTISR GRMEQDLLML KTYNFNAVRL SHYPNDEYFY QLCDKYGIYV
VDEANLESHG MGYDITKTLG NKPNWELAHL ERIERMVERD KNHPSIIIWS MGNEAGNGYN
FYRSYLWLKD RDPSRPIQYE RATVAGWEGA NLKFDWDSDI VDPMYSSPKG MEEYIAANPN
PSRPFIQCEY AHAMGNSLGN LKDYWDVIRA HKNFQGGFIW DMIDQSVYKT KPDGTKEFAY
GGDFGPEDVP SDNNFLNNGV FNPEREPNPH AFEAKSVLQE IHTTWANIDK FEVSVFNEFF
FKNLSNVQLN WELVLDGKPV QNGNITELTN APQETRTYTL NIKEPKKQYQ EAFINISYTL
KNPEPFIESG VEIAKEQLHF KGTWKNNQSV SPSGSFKVTK TNESISFKSD VTELSFNKTT
GLLNTYNFQN DSILKPGYTL QPNFWRAPND NDMGAIFQKK LLPWKTVSNA PKLIDFSYKL
DKNGIVSAKA QYELKDVFAN LTLNYTFNSL GVLNVSQDLQ IEADKETPLL PRFGMKLTLP
DGFDALNYYG RGPFENYSDR NYSSDVGLYK QTVSEQYYPY IRPQETGNKT DVRWLTLMGK
NTQLLVTSNA LFSSTALHFL DDDLDDGLEK DQRNASDISE QDLTTLKIDL TQMGVGSIDS
WGAWPMEKYL LRAKHYNYQF TITPSTK
//
