ID A0A0D7W1P5_9FLAO Unreviewed; 870 AA.
AC A0A0D7W1P5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=PK35_09835 {ECO:0000313|EMBL:KJD32628.1};
OS Tamlana nanhaiensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Tamlana.
OX NCBI_TaxID=1382798 {ECO:0000313|EMBL:KJD32628.1, ECO:0000313|Proteomes:UP000032361};
RN [1] {ECO:0000313|EMBL:KJD32628.1, ECO:0000313|Proteomes:UP000032361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FHC16 {ECO:0000313|EMBL:KJD32628.1,
RC ECO:0000313|Proteomes:UP000032361};
RX PubMed=25735434; DOI=10.1007/s10482-015-0410-x;
RA Liu X., Lai Q., Du Y., Li G., Sun F., Shao Z.;
RT "Tamlana nanhaiensis sp. nov., isolated from surface seawater collected
RT from the South China Sea.";
RL Antonie Van Leeuwenhoek 107:1189-1196(2015).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJD32628.1}.
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DR EMBL; JTDV01000008; KJD32628.1; -; Genomic_DNA.
DR RefSeq; WP_044626675.1; NZ_JTDV01000008.1.
DR AlphaFoldDB; A0A0D7W1P5; -.
DR STRING; 1382798.PK35_09835; -.
DR PATRIC; fig|1382798.3.peg.3319; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000032361; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000032361}.
FT DOMAIN 692..708
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 618..625
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 870 AA; 97959 MW; CD61B6D4527E3525 CRC64;
MAKKAKKETP LMKQYNAIKA KYPDALLLFR VGDFYETFGD DAVKAAGILG IILTKRGAGS
ENETALAGFP HHSLNTYLPK LVKAGERVAI CDQLEDPKQT KTIVKRGVTE LVTPGVALND
EVLTSKSNNF LCSVYFDKKT IGIAFLDIST GEFLTSQGNA EYIDKLIQNF NPSEVLVSKQ
KKLAFKDTFG DDLHTFYLED WVYQTDYANE TLIKHFNTKT LKGFGVEDLH EGIIASGSIL
HYLGETQHNK LKHITAIARI AEDDYVWMDK FTIRNLELYH STNNNAVTLL NIIDKTISPM
GGRMLKRWLA LPLKSSDKIK QRHEVVHFLK TENGTLQKIQ NHIKHIGDLE RLISKTATGK
VNPREVIQLK NSLESIVPIK SIATNCNNES LQVIGDRLQG CDVLREKIKQ TLNEDAPVNV
LKGNTIAEGF SKELDELRGL SKSGKDYLDN MLERESERTG IPSLKIASNN VFGYYIEVRN
THKDKVPAEW IRKQTLVSAE RYITEELKEY ETKILGAEER ILAIEQKLFA DLVSWMNLYI
KSVQQNAFLI GQLDCLCGFA QLASDNNYVY PNIDDSYDLV IKEGRHPVIE KQLPLGEAYI
ANDIYLDRAE QQIIMITGPN MSGKSAILRQ TALIVLLAQI GSFVPAKEAK IGLVDKIFTR
VGASDNISMG ESTFMVEMNE TASILNNISD RSLVLLDEIG RGTSTYDGIS IAWAISEYLH
QHPAKPKTLF ATHYHELNEM TETFERIKNF NVSVKELEDN VLFLRKLVKG GSAHSFGIHV
AKMAGMPQLV LQRANKILNR LEQSHSSDEL TDKVKTLEND MQLSFFNLDD PLLENIKEEI
LSTDIDTLTP VEALMKLNEI KRMLVKKKQA
//
