ID A0A0D7W2Q9_9FLAO Unreviewed; 802 AA.
AC A0A0D7W2Q9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KJD33314.1};
GN ORFNames=PK35_05500 {ECO:0000313|EMBL:KJD33314.1};
OS Tamlana nanhaiensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Tamlana.
OX NCBI_TaxID=1382798 {ECO:0000313|EMBL:KJD33314.1, ECO:0000313|Proteomes:UP000032361};
RN [1] {ECO:0000313|EMBL:KJD33314.1, ECO:0000313|Proteomes:UP000032361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FHC16 {ECO:0000313|EMBL:KJD33314.1,
RC ECO:0000313|Proteomes:UP000032361};
RX PubMed=25735434; DOI=10.1007/s10482-015-0410-x;
RA Liu X., Lai Q., Du Y., Li G., Sun F., Shao Z.;
RT "Tamlana nanhaiensis sp. nov., isolated from surface seawater collected
RT from the South China Sea.";
RL Antonie Van Leeuwenhoek 107:1189-1196(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJD33314.1}.
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DR EMBL; JTDV01000003; KJD33314.1; -; Genomic_DNA.
DR RefSeq; WP_044625706.1; NZ_JTDV01000003.1.
DR AlphaFoldDB; A0A0D7W2Q9; -.
DR STRING; 1382798.PK35_05500; -.
DR PATRIC; fig|1382798.3.peg.2417; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000032361; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000032361}.
FT DOMAIN 8..206
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 209..308
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 384..427
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 802 AA; 88326 MW; 29F30ED386486014 CRC64;
MSKRIINKVA VIGSGIMGSG IACHFANIGV EVLLLDIVPR DLTDAEKAKG LTLEDKVVRN
RLVNTSLQTA LKSKPSPIYH QSFASRISTG NLEDDITKVA DVDWIIEVVV ERLDIKKKVF
ENLDKHRKPG TLITSNTSGI PIKFMSEGRS DDFQAHFCGT HFFNPARYLK LFEIIPGPKT
SQDVLDFLNG YGEQFLGKTS VIAKDTPAFI GNRIGIFGIQ SLFHQVKDLG LTIEEVDKLT
GPVIGRPKSA TFRTVDVVGL DTLVHVANGI YDNCPDDEAH DLFKLPDFIN TMMENKWLGS
KTGQGFYKKV KGDNGKSEIL SLDLDTLEYR SKKSAKFATL ELTKSVDKVI NRFPILVGGK
DKAGDFYRKN FAAMFAYVSH RVPEITDEFY KIDDAMKAGF GWEHGPFQIW DAIGVEKGLE
IMKAEGKEPA SWVTEMLASG SKSFYTVKDG ASYFYDIPSK TQTKVPGQDA FIILDNIRKS
KEVFKNSGVV IEDLGDGILN CEFQSKMNTI GGDVLAGLNK AVDLAEKDFQ GLVIGNQAAN
FSVGANIGMI FMMAVEQEYD ELNMAIKYFQ DTMMRMRYSS IPTVAAPHGM TLGGGCELSL
HADKVVAAAE TYIGLVEFGV GVIPGGGGSK EMALRASDLF HKGDVKLNVL QEYFLTIGMA
KVSTSAYEAF DLGVLQKGKD VVVVNKDRQI ATAKAYAKLM AEQGYTQPIK RKDVKVLGKQ
ALGMFLVGTD SMEASNYISE HDQKIANKLA YVMAGGDLSE PTAVSEQYLL DLEREAFLSL
CTERKTLERI QHMLKTGKPL RN
//
