ID A0A0D7W417_9FLAO Unreviewed; 588 AA.
AC A0A0D7W417;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Phenylalanine 4-monooxygenase {ECO:0000313|EMBL:KJD32607.1};
GN ORFNames=PK35_10435 {ECO:0000313|EMBL:KJD32607.1};
OS Tamlana nanhaiensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Tamlana.
OX NCBI_TaxID=1382798 {ECO:0000313|EMBL:KJD32607.1, ECO:0000313|Proteomes:UP000032361};
RN [1] {ECO:0000313|EMBL:KJD32607.1, ECO:0000313|Proteomes:UP000032361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FHC16 {ECO:0000313|EMBL:KJD32607.1,
RC ECO:0000313|Proteomes:UP000032361};
RX PubMed=25735434; DOI=10.1007/s10482-015-0410-x;
RA Liu X., Lai Q., Du Y., Li G., Sun F., Shao Z.;
RT "Tamlana nanhaiensis sp. nov., isolated from surface seawater collected
RT from the South China Sea.";
RL Antonie Van Leeuwenhoek 107:1189-1196(2015).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJD32607.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JTDV01000008; KJD32607.1; -; Genomic_DNA.
DR RefSeq; WP_044626654.1; NZ_JTDV01000008.1.
DR AlphaFoldDB; A0A0D7W417; -.
DR STRING; 1382798.PK35_10435; -.
DR PATRIC; fig|1382798.3.peg.3438; -.
DR OrthoDB; 9780502at2; -.
DR Proteomes; UP000032361; Unassembled WGS sequence.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR CDD; cd00361; arom_aa_hydroxylase; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:KJD32607.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000032361}.
FT DOMAIN 1..261
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 131
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 136
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 221
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 588 AA; 65509 MW; D05D4DF9FD892012 CRC64;
MQSNIEENDV LKRLPKHLKQ FIKPQNYQDY SAIDQAVWRY VMRKNVDFLK TVAHKSYLNG
LKQTGISINS IPNMYGMNRI LKDIGWAAVA VDGFIPPNAF MEFQAYNVLV IASDIRQLEH
IEYTPAPDII HEGAGHAPII ANPEYAEYLR RFGEIGCKAI SSAKDYELYE AVRHLSIIKE
APHASDADIA SAENTVDQLQ KNMGEPSEMA LIRNLHWWTV EYGLIGTPEN PKIYGAGLLS
SIGESAWCMT DHVKKLPYNV QATFQDFDIT KPQPQLFVTP DFAHLSLVLE EFANTMALRK
GGLSGIKKLI NSQALGSIEL STGIQISGVF SDVIEHDGLP IYFQTTGKTA LAYREKELVG
HGIKTHEHGF GSPIGKLKGI NIAIEDMSPR DLSAYNIFEE KTVSLDFEGG ISISGEIITG
KRNLQGKIIL ISFKNCTVTH GDTVLFKPKH GIYHMAVGKA IVSAFSGPAD LNSFDLITHK
VSSQTIKIEK SKSQLRLESL YKQVRDYRDG KNTTISRTKV LEVLISEHPN DWLLPIELYE
LAFKGNEKTL CKSISQHLET IKQNRPQVGK LIDDGLAIVD DAVVSKDS
//
