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Database: UniProt
Entry: A0A0D8CKW4_9PROT
LinkDB: A0A0D8CKW4_9PROT
Original site: A0A0D8CKW4_9PROT 
ID   A0A0D8CKW4_9PROT        Unreviewed;       714 AA.
AC   A0A0D8CKW4;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=GTP pyrophosphokinase rsh {ECO:0000256|ARBA:ARBA00014315};
DE            EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE   AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE   AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
GN   ORFNames=UF64_00765 {ECO:0000313|EMBL:KJE36920.1};
OS   Thalassospira sp. HJ.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Thalassospiraceae; Thalassospira.
OX   NCBI_TaxID=1616823 {ECO:0000313|EMBL:KJE36920.1, ECO:0000313|Proteomes:UP000032356};
RN   [1] {ECO:0000313|EMBL:KJE36920.1, ECO:0000313|Proteomes:UP000032356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HJ {ECO:0000313|EMBL:KJE36920.1,
RC   ECO:0000313|Proteomes:UP000032356};
RA   Kiseleva L., Garushyants S.K., Goryanin I.;
RT   "Complete genome of Thalassospira sp. strain HJ.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC       is a mediator of the stringent response that coordinates a variety of
CC       cellular activities in response to changes in nutritional abundance.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJE36920.1}.
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DR   EMBL; JYII01000003; KJE36920.1; -; Genomic_DNA.
DR   RefSeq; WP_044826725.1; NZ_JYII01000003.1.
DR   AlphaFoldDB; A0A0D8CKW4; -.
DR   STRING; 1616823.UF64_00765; -.
DR   PATRIC; fig|1616823.3.peg.3468; -.
DR   OrthoDB; 9805041at2; -.
DR   Proteomes; UP000032356; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04876; ACT_RelA-SpoT; 1.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RSH; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA/SpoT.
DR   NCBIfam; TIGR00691; spoT_relA; 1.
DR   PANTHER; PTHR21262:SF36; BIFUNCTIONAL (P)PPGPP SYNTHASE/HYDROLASE SPOT; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF19296; RelA_AH_RIS; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:KJE36920.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032356};
KW   Transferase {ECO:0000313|EMBL:KJE36920.1}.
FT   DOMAIN          45..144
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   DOMAIN          383..448
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
FT   DOMAIN          640..714
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   714 AA;  80874 MW;  513E8B09CA5BBAF8 CRC64;
     MMRQYELVER VKAYDPDACE TTLNRAYVYA TQKHGSQKRA SGDPYFSHPI EVAGILTNYK
     LDCDTIITAL LHDTIEDTDA TPEEITKLFG SNIMKLVDGV TKLTQIELKS ADSKQAENFR
     KLLLAMSEDI RVLLVKLADR LHNMRTLHYI SKPEKRVRIA AETLEIYAPL AERIGMHDIK
     EELEDLAFQH INPEARDSIL ARLEFLRQKD DNVVSRIVSE LTDVVSRQGL KVDIYGREKR
     PYSIWQKMQR KNITFGELSD IMAFRVLVED MPQCYEVLGY LHANYKVVPG RFKDYISTPK
     PNGYRSIHTT VLGPENHRIE VQIRTRQMHE VNENGVAAHW AYKQETPTGE QKEGVQYRWL
     RDLLDILEHA SEPEEFLEHT KLAMFQDQVF CFSPKGDVIA LPARATPVDF AYMIHTHIGD
     TCVGAKVNGA MVPLRTVLNN GDQVEIVTSK AQTPNPTWER FVVSGKARAR IRRFIRQQQE
     DQYKDLGKAI LQKAFRQEGY DYSDKALEGV LKIFKQPSVE ALLTLVGAGH HTGREVVHAV
     FPGTKDKETA RKVVPLDKVR ARKHEHAIPI KGLIPGMAVH YAGCCHPLPG DRIVGIVTTG
     KGVTIHTIDC DTLETFTEQP ERWLDVGWDN EGEPEHFIGR LGLTVGHEQG ALSSITSVIA
     KNHGNITNLR FTNRTTDFFE MLIDIDVVDV KHLTNIIAAL RATPVVNAVE RARG
//
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