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Database: UniProt
Entry: A0A0D8FWG7_9ACTN
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ID   A0A0D8FWG7_9ACTN        Unreviewed;       483 AA.
AC   A0A0D8FWG7;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Isocitrate dehydrogenase [NADP] {ECO:0000256|ARBA:ARBA00019562};
DE            EC=1.1.1.42 {ECO:0000256|ARBA:ARBA00013013};
DE   AltName: Full=IDP {ECO:0000256|ARBA:ARBA00029765};
DE   AltName: Full=NADP(+)-specific ICDH {ECO:0000256|ARBA:ARBA00029990};
DE   AltName: Full=Oxalosuccinate decarboxylase {ECO:0000256|ARBA:ARBA00031098};
GN   Name=icd1 {ECO:0000313|EMBL:KJE77635.1};
GN   ORFNames=FEAC_07460 {ECO:0000313|EMBL:KJE77635.1};
OS   Ferrimicrobium acidiphilum DSM 19497.
OC   Bacteria; Actinomycetota; Acidimicrobiia; Acidimicrobiales;
OC   Acidimicrobiaceae; Ferrimicrobium.
OX   NCBI_TaxID=1121877 {ECO:0000313|EMBL:KJE77635.1, ECO:0000313|Proteomes:UP000032336};
RN   [1] {ECO:0000313|EMBL:KJE77635.1, ECO:0000313|Proteomes:UP000032336}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T23 {ECO:0000313|EMBL:KJE77635.1,
RC   ECO:0000313|Proteomes:UP000032336};
RA   Poehlein A., Eisen S., Schloemann M., Johnson B.D., Daniel R., Muehling M.;
RT   "Draft genome of the acidophilic iron oxidizer Ferrimicrobium acidiphilum
RT   strain T23.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH;
CC         Xref=Rhea:RHEA:19629, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.42;
CC         Evidence={ECO:0000256|ARBA:ARBA00023554};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJE77635.1}.
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DR   EMBL; JXUW01000004; KJE77635.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D8FWG7; -.
DR   STRING; 1121877.FEAC_07460; -.
DR   PATRIC; fig|1121877.4.peg.794; -.
DR   eggNOG; COG0473; Bacteria.
DR   Proteomes; UP000032336; Unassembled WGS sequence.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.1570; -; 1.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR014273; Isocitrate_DH_bac-typ.
DR   InterPro; IPR040978; Isocitrate_DH_TT1725_C.
DR   InterPro; IPR046997; Isocitrate_DH_TT1725_C_sf.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   NCBIfam; TIGR02924; ICDH_alpha; 1.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF43; ISOCITRATE DEHYDROGENASE (NADP(+)); 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   Pfam; PF18324; Isocitrate_DH_C_bact; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   3: Inferred from homology;
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000313|EMBL:KJE77635.1};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032336}.
FT   DOMAIN          8..339
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   483 AA;  52969 MW;  8FFCA6810DD132F5 CRC64;
     MSIASKKHIT VAEGDGIGPE IMEATLRILA TAGADLDIER ITIGANVFDQ GISSGIEPGA
     WDSLRRTKVL LKAPITTPQG GGFKSVNVTI RKTFGLYANI RPCISYAPYI PTQHPGMDLV
     IIRENEEDLY GGIEHRQTQD VFQTLKLITR PGSERIIRYA FEYARRYHRR KVTSFTKDNI
     MKLSDGTFHK IFNEVAEEYP DIESEHWIID IGTAKLATAP EQFDVLVLPN LYGDILSDVA
     AEITGSVGLA GSANIGEEIA MFEAIHGSAP PLAGKNVANP SGLLMGAVLM LVHLGLGSTA
     TSIHNAWLRT IEDGIHTPDI YTENRSTKQV GTDAFADAVI ERLGETPQKL PSTLYPDSEE
     PITVKLHDRP IEVKTLEGID IFVEFRGEVD DLGHQIEAHL NPNLTLVMIS NRGQKVYPNG
     AAETFCVDHW RCRFQAREPG IVLSTADLID QLARLNAAGL PFIKTEGLFA FDDIPGYSLS
     QGQ
//
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