ID A0A0D8JT57_COCIM Unreviewed; 496 AA.
AC A0A0D8JT57;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=CIMG_11625 {ECO:0000313|EMBL:KJF60477.1};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:KJF60477.1, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG704912; KJF60477.1; -; Genomic_DNA.
DR RefSeq; XP_012214043.1; XM_012358620.1.
DR AlphaFoldDB; A0A0D8JT57; -.
DR STRING; 246410.A0A0D8JT57; -.
DR GeneID; 24163796; -.
DR KEGG; cim:CIMG_11625; -.
DR VEuPathDB; FungiDB:CIMG_11625; -.
DR InParanoid; A0A0D8JT57; -.
DR OMA; GWQWTPA; -.
DR OrthoDB; 3202908at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR43678:SF1; BETA-N-ACETYLHEXOSAMINIDASE; 1.
DR PANTHER; PTHR43678; PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 175..245
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
SQ SEQUENCE 496 AA; 55599 MW; C1ADC5E6FC117F01 CRC64;
MSLHFPNRVD KETWKKSLSS VPKTIYIDSS FTQIKDKDGL THIPPSAYEF AETFASDLEW
ISRTSWKLER VDRISKCGKG IYLGKSAGSA SKLIYQNGEV TEEARFRLFT TGYMLDCGRK
LVLAVVSQGN VHVRLVLQMS EFRYHLMDNY PLNHGPNETW NRVYLHFSPR PEDPELNPLV
ERRNETLSRR EFEDLQRHCV SRGVTVIPEI EAPGHALVIT RWKPEFINFT AGKAVRIWGT
YEPAEHLSID KKLPSFNTGS ITNPTCTSLN QLDRENLQWE PSLIDPYNIE EQLDSKSKGL
KGATMAAWND NGYDASTQLE AYYTMKMGIP LLASRSWSGS RGVKLDEAGS TESLWILSDM
APAQSSERWL AVEMNGIDLP DSLVSWKRSD FDQKKGPLIM GLGSKGIDYP LMLDVTGPFT
LSSSDSILLL DDSGSLCFLA NGISYPLCHV DERDGFDPGH PGRIWINASS SSHEPVKVPL
NASITIKTDI LSGSLI
//
