ID A0A0D8JV89_COCIM Unreviewed; 771 AA.
AC A0A0D8JV89;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=CCR4-NOT core complex subunit Not4 {ECO:0000313|EMBL:KJF60178.1};
GN ORFNames=CIMG_01358 {ECO:0000313|EMBL:KJF60178.1};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:KJF60178.1, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704911; KJF60178.1; -; Genomic_DNA.
DR RefSeq; XP_004445815.1; XM_004445758.1.
DR AlphaFoldDB; A0A0D8JV89; -.
DR GeneID; 4566714; -.
DR VEuPathDB; FungiDB:CIMG_01358; -.
DR OrthoDB; 1748at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0030014; C:CCR4-NOT complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd16618; mRING-HC-C4C4_CNOT4; 1.
DR CDD; cd12438; RRM_CNOT4; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034261; CNOT4_RRM.
DR InterPro; IPR039780; Mot2.
DR InterPro; IPR039515; NOT4_mRING-HC-C4C4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12603; CCR4-NOT TRANSCRIPTION COMPLEX RELATED; 1.
DR PANTHER; PTHR12603:SF0; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF14570; zf-RING_4; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 18..62
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 121..208
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 230..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 77..110
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 238..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 771 AA; 83400 MW; C452F0E07CA54776 CRC64;
MASRTQNDTV IDDDDEICPL CIEEFDLSDK NFKPCPCGYQ ICQFCYNNIK THSEEGRCPN
CRRVYDENTI QYRVPDADEL KADLALKHRK AAAAKKKEQE KREIEASSRK NLAGVRVVQK
NLVYVIGLNP TIRDENQLLQ TLRGDQYFGQ YGEIEKIVVS KAKPGGNPNQ GIGVYVTFAK
KSDAASCIAA VDGSANGDRV LRAQYGTTKY CSSFLRNEQC NNRNCTFLHE TGEDSDSFSR
QDLSSMNTIS SQRPHPNYPN VSANQSRAYT PGSQSGPSSS LSMQRHTNKD EGTRMPANDS
PALPSSASWA NKDALAHRTR RPSVAASCGT PSPKPATATI ATKPEESRAA TEKRTHQNVE
ESRQHTPTPG PSSRLEQRDS VSPRRPLSVS QDRGMVLYNL VKAINSPEFR FQFSAAGLSA
DELAFIENHP SLIDPYGGVK RRAMREKAEQ ERAKQEVEAK MLLHANQPEE ETLEGGSSQL
GGEPEESHSG PGPAGRSGRE QQAIQPPSQQ ATASSSAVGS PVSAGHQFQS LNVNGRALTP
LQQQQLMLLK STTGQQSGLL DQLQTSSING YDHNPLSRPS AFQNQMPPVG AISGHARQSS
RFSFANESNA KNPNHRLLSQ QAAVMQASTT NPMATANAQQ HGLSSHFFTS GVQGPPPGLK
TAGTPPVSGG GMFAQGHGFT STMNNNLGLN VKQDGNADLM RELMRARSGT SGGGVQTLEA
TKLDLADPSI LQARMHQSNA TAVAGQGLYG SQGQGGYNHS NMVFNGGFAR W
//