ID A0A0D8X7E7_DICVI Unreviewed; 483 AA.
AC A0A0D8X7E7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 22-FEB-2023, entry version 36.
DE RecName: Full=Zinc metalloproteinase {ECO:0000256|PIRNR:PIRNR036365};
GN ORFNames=DICVIV_13585 {ECO:0000313|EMBL:KJH40458.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Trichostrongyloidea; Dictyocaulidae; Dictyocaulinae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH40458.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH40458.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH40458.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR036365}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; KN717200; KJH40458.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8X7E7; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 2.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR017050; Metallopeptidase_nem.
DR InterPro; IPR001506; Peptidase_M12A.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR10127; DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING; 1.
DR PANTHER; PTHR10127:SF780; ZINC METALLOPROTEINASE NAS-13; 1.
DR Pfam; PF01400; Astacin; 1.
DR PIRSF; PIRSF036365; Astacin_nematoda; 2.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Secreted {ECO:0000256|PIRNR:PIRNR036365};
KW Signal {ECO:0000256|PIRNR:PIRNR036365}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|PIRNR:PIRNR036365"
FT CHAIN 23..483
FT /note="Zinc metalloproteinase"
FT /evidence="ECO:0000256|PIRNR:PIRNR036365"
FT /id="PRO_5002335562"
FT DOMAIN 318..436
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 25..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 54828 MW; 3BE677B27F9EB0D7 CRC64;
MKPILSPLLL FCIGVELYNA NALGENRGGD ESYRKELEEE SQQLENETDA ENTKVFLEKL
LNMEEKIENE LKLTPQQNEE LNFTMRNYVG MRIDHVDDNG DTIEEVNKYN RIDKALYQGD
IILSQAQAEE IIEENEGNAE NRTKRQAMNL GRHRNSIWPN NRVYYTYVNA SDPAIRAFEQ
AVKDWSNATC IDFYRSDTGI LKRNTASQFK KQSKQSNNNY NITYDYGGVM HYGPMIVSKN
RKPVVVTHDI NYMQTLGSPI ISFYEKLMMN VHYKCNDCTK KPSANCQNGG FAHPRNCMVC
ICPSGYGGDL CDRRPDGCGS VLKANESYQF LVDTVGNKSR PKDRVQFYTC NYWIEAQLGE
KIEVIFDNFT KRLGAEGCKY AGVEIKTGSD KRHTGYRFCS SSNIDTRLVS TYNVVPIITY
NLAAHPSTTT LRYRSIRRDA DAPKSTADPQ TSTRFPELQT TIQPTVLTTS TPSPKNLTTA
TAP
//