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Database: UniProt
Entry: A0A0D8X7E7_DICVI
LinkDB: A0A0D8X7E7_DICVI
Original site: A0A0D8X7E7_DICVI 
ID   A0A0D8X7E7_DICVI        Unreviewed;       483 AA.
AC   A0A0D8X7E7;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   22-FEB-2023, entry version 36.
DE   RecName: Full=Zinc metalloproteinase {ECO:0000256|PIRNR:PIRNR036365};
GN   ORFNames=DICVIV_13585 {ECO:0000313|EMBL:KJH40458.1};
OS   Dictyocaulus viviparus (Bovine lungworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Trichostrongyloidea; Dictyocaulidae; Dictyocaulinae; Dictyocaulus.
OX   NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH40458.1, ECO:0000313|Proteomes:UP000053766};
RN   [1] {ECO:0000313|EMBL:KJH40458.1, ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH40458.1,
RC   ECO:0000313|Proteomes:UP000053766};
RA   Mitreva M.;
RT   "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX   PubMed=26856411; DOI=10.1038/srep20316;
RA   McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA   Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA   Sternberg P.W., Gasser R.B., Mitreva M.;
RT   "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT   lungworm biology and support future intervention.";
RL   Sci. Rep. 6:20316-20316(2016).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR036365}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; KN717200; KJH40458.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D8X7E7; -.
DR   Proteomes; UP000053766; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 2.
DR   Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR017050; Metallopeptidase_nem.
DR   InterPro; IPR001506; Peptidase_M12A.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR10127; DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING; 1.
DR   PANTHER; PTHR10127:SF780; ZINC METALLOPROTEINASE NAS-13; 1.
DR   Pfam; PF01400; Astacin; 1.
DR   PIRSF; PIRSF036365; Astacin_nematoda; 2.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
DR   SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR   PROSITE; PS01180; CUB; 1.
DR   PROSITE; PS01186; EGF_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW   Secreted {ECO:0000256|PIRNR:PIRNR036365};
KW   Signal {ECO:0000256|PIRNR:PIRNR036365}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|PIRNR:PIRNR036365"
FT   CHAIN           23..483
FT                   /note="Zinc metalloproteinase"
FT                   /evidence="ECO:0000256|PIRNR:PIRNR036365"
FT                   /id="PRO_5002335562"
FT   DOMAIN          318..436
FT                   /note="CUB"
FT                   /evidence="ECO:0000259|PROSITE:PS01180"
FT   REGION          25..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        445..483
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   483 AA;  54828 MW;  3BE677B27F9EB0D7 CRC64;
     MKPILSPLLL FCIGVELYNA NALGENRGGD ESYRKELEEE SQQLENETDA ENTKVFLEKL
     LNMEEKIENE LKLTPQQNEE LNFTMRNYVG MRIDHVDDNG DTIEEVNKYN RIDKALYQGD
     IILSQAQAEE IIEENEGNAE NRTKRQAMNL GRHRNSIWPN NRVYYTYVNA SDPAIRAFEQ
     AVKDWSNATC IDFYRSDTGI LKRNTASQFK KQSKQSNNNY NITYDYGGVM HYGPMIVSKN
     RKPVVVTHDI NYMQTLGSPI ISFYEKLMMN VHYKCNDCTK KPSANCQNGG FAHPRNCMVC
     ICPSGYGGDL CDRRPDGCGS VLKANESYQF LVDTVGNKSR PKDRVQFYTC NYWIEAQLGE
     KIEVIFDNFT KRLGAEGCKY AGVEIKTGSD KRHTGYRFCS SSNIDTRLVS TYNVVPIITY
     NLAAHPSTTT LRYRSIRRDA DAPKSTADPQ TSTRFPELQT TIQPTVLTTS TPSPKNLTTA
     TAP
//
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