GenomeNet

Database: UniProt
Entry: A0A0D8X9K1_DICVI
LinkDB: A0A0D8X9K1_DICVI
Original site: A0A0D8X9K1_DICVI 
ID   A0A0D8X9K1_DICVI        Unreviewed;       443 AA.
AC   A0A0D8X9K1;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   31-JUL-2019, entry version 23.
DE   SubName: Full=Neurotransmitter-gated ion-channel ligand binding domain protein {ECO:0000313|EMBL:KJH41265.1};
GN   ORFNames=DICVIV_12762 {ECO:0000313|EMBL:KJH41265.1};
OS   Dictyocaulus viviparus (Bovine lungworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Trichostrongyloidea; Dictyocaulidae; Dictyocaulinae; Dictyocaulus.
OX   NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH41265.1, ECO:0000313|Proteomes:UP000053766};
RN   [1] {ECO:0000313|EMBL:KJH41265.1, ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH41265.1,
RC   ECO:0000313|Proteomes:UP000053766};
RA   Mitreva M.;
RT   "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX   PubMed=26856411; DOI=10.1038/srep20316;
RA   McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA   Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA   Sternberg P.W., Gasser R.B., Mitreva M.;
RT   "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT   lungworm biology and support future intervention.";
RL   Sci. Rep. 6:20316-20316(2016).
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|SAAS:SAAS00978283}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; KN716864; KJH41265.1; -; Genomic_DNA.
DR   Proteomes; UP000053766; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053766};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00874916};
KW   Ion channel {ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00457659}.
FT   TRANSMEM    392    415       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    422    440       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      131    305       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   REGION        1     41       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS     13     27       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   443 AA;  51370 MW;  7610EEB02BBBFECD CRC64;
     MVSPEKIADS FRDVEQQSFS SDIHDGKNVS ASESKAEQGE REFSGEMYHF NKWTEPTRTL
     YDTIILKSAP ELDKERRTFD TAILEKELMI KTAATNTNEL KEKLKNRTNL EGTVGNRHRD
     YGSSYILPVL LSVNYDNNTV PTVFSDVPVI VAVQMNILYL ANFDSELMEY SIDLEMQLSW
     FDLRLVNNYT KPIRIREKQI LDLVWKPNPY FVNSKFSHFH GVSFPNFRMR VFPDGLVKYT
     MRVTSVCNCF MLFCLYPHDR QTCDLRISSI AYPSTFVQFV WHSDPVSFQS EIALPELHIQ
     RVWTGRCNVE GKLIRSSCIR LVFELERDGS RFIVEKYIPS TLAMMFAWVA PYVPYNYEDV
     RIITPITVLL TLVQMEKGDK EIRTSYLTSM DVWFAAMKAF TVISLLESLT VLALIKRSRA
     MLLLFDFAQI LFILTPFYAA RDG
//
DBGET integrated database retrieval system