ID A0A0D8XGS0_DICVI Unreviewed; 643 AA.
AC A0A0D8XGS0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=DICVIV_12458 {ECO:0000313|EMBL:KJH41566.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH41566.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH41566.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH41566.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436};
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DR EMBL; KN716797; KJH41566.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8XGS0; -.
DR STRING; 29172.A0A0D8XGS0; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd06352; PBP1_NPR_GC-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF503; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-9; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KJH41566.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 380..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 437..643
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 643 AA; 72654 MW; 9D36EE0AD1F89A01 CRC64;
MESCNKFSGV ENAAYLHYLK NATIYFGPGC NDEMLVIGRL APRWNVPIIA HMSGDDALSD
RSVFTTLGSV ALTSASEMAR ATLTYLQLNN WHEVGFVRAS KNYDRLSLHS LANLLKNENV
KVNVIVDVDQ SAPPDQIVAS GKLQQLKSNA RIIIVELGMD VNSATNFMLA AYRSEMKSND
YVYIIPWLAH TKFHYPWEAT TVDKQEVKAA FENTIIITAH GYDKKFSDDF QEKFSQATGI
LSSHYATLTY MSLYDALFLY GLALRDAYEE IGGYDVHRNG SLIWSKMTNR QFIGATGQVL
MNNKAIRVPS YATYYTTNGT LRIVVELEAK NVDNAQCEKK PDQCSEHVAR EIEQFYWPSS
SGELPKDVPR CGFTGSKCDY SAYFIIMGVV AFLIAIGPLS YFVYLKQKER LLYEMTWRIP
REITSHLSTI FKRSDHSLAS RSQSSGSFSG SLGSKQLISA KQAMSNGVRI AIKRFQQIRN
ITFPKSELKV LKELKLIENE NLNKFYGIAF NQQNEFIVMW VFCSRGSLED ILFNDELKLG
RNFQVSFAKD VVKGLSFLHG SPLIYHGLLC LQNCLVDSNW TVKLTNFGTE LIISEKLYHN
EIKTIVGEGE DETDRIADRS NFLVILFRFS IVILAQKEAA KKA
//
