ID   A0A0D8XI95_DICVI        Unreviewed;      1169 AA.
AC   A0A0D8XI95;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=RhoGEF domain protein {ECO:0000313|EMBL:KJH44313.1};
GN   ORFNames=DICVIV_09655 {ECO:0000313|EMBL:KJH44313.1};
OS   Dictyocaulus viviparus (Bovine lungworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX   NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH44313.1, ECO:0000313|Proteomes:UP000053766};
RN   [1] {ECO:0000313|EMBL:KJH44313.1, ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH44313.1,
RC   ECO:0000313|Proteomes:UP000053766};
RA   Mitreva M.;
RT   "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX   PubMed=26856411; DOI=10.1038/srep20316;
RA   McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA   Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA   Sternberg P.W., Gasser R.B., Mitreva M.;
RT   "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT   lungworm biology and support future intervention.";
RL   Sci. Rep. 6:20316-20316(2016).
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DR   EMBL; KN716483; KJH44313.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D8XI95; -.
DR   STRING; 29172.A0A0D8XI95; -.
DR   Proteomes; UP000053766; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF15; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053766}.
FT   DOMAIN          233..456
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   COILED          492..523
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1169 AA;  131177 MW;  AA5C3CF9FAF6166B CRC64;
     MQQVGQDDSD FCGEDTLTEI EELQDAAKSI QSLQRVLKRP QHSTDRGAFS YVMLSVFSDA
     DESTSVVVDP SADGRVSGIS TRLGHPRGVM QFLPSMGNDL FMSPTNTYRG RASLSRKTSA
     PDAFVSLSVL SESELNPITS RNRRRGVVDD FLETSLEQKN SESLAGVSRF SKLLRSFRSD
     QNPSETHSTI SWRPYGFSES AGEECRMEDS LLQADILLWK KRSHASLRKH YSVRNLAARE
     LYDTEKSFVE GLEFLVTANR FRVQKYMRPL RQPLECTLIE PGLADKIFYK VPEVLAHHQV
     LLAALSSRIE EWNKESVIGD VLLSHVSIRY HICRIIQFFS YFFLQSSLRS VPYPFDLLIN
     FSKQSMVDTY ISFVDNFKYA KAAIAQARGK PSFEKYYNRC CRDHRNKLDL DSLLISPIQR
     VPRYELLVKQ LIKHTPTEHA DHEVLLRAQR HIHNLALTKI QEKELYNIKT MSHSNLIRGS
     KYSVEVSKNF VIKVAINQHK EANEQMEQRL REIEAIVDGL DDLVSTGRNL VRYDMVQMRC
     RGDEKRQRCV FTLSDQLVLT SVRRKNPTRN TKLITQSADF LDSNRFKLII KISLDDVEIA
     KDTLSILQDA EQTIDVVRED QKVIRKVIEL ANLIKGSKEK LLTILDEMSS ENNRRLRLLN
     DQMLSNPDLT TVQLAIATAN GVETVPLEFG SAEKRAIWET AFRESKNALI NQQISAPPAQ
     LKSVIVHQTR PGLQLCAGTI VPGKRSDSAP YIWLCASDKF SGQVAVLSLE NGDPCIESCA
     GIGNAAVTAT CTVPPPPSTK RKRKVRSQKS LEVFSRNETL FDRISSGESS ESDDDTSTGQ
     ITVWIGNGDG EVFVVNSTER IRTRARERVA RLSDPVTAIT NAAGYVYVAT ASPSSVQLLR
     FHTTAERLWD LDAPIHIGHS LTRPILAMCQ VGKRLLLVSG HQIHAMDTEG SGWEKPVDIV
     ASTDFLQLMT SSGSVIFCCG RRSTNVYVVN AFSLKVFNHF GISACVRTHL AGRDDIIREH
     KMGCLRISCI TAATSQLWIG TSAGFVISTP LHCAKTQPNP PLSDFFSIPV REMGHSGPCR
     VLIPINISLN RKAKRMSLNV PSQQASQVKL SLFLSERELR CFLMIFSYTK LLVASCGDGL
     DDLNGNQDPT NDAVNHVIFW KCPQLCDTS
//