ID A0A0D8XLR1_DICVI Unreviewed; 1172 AA.
AC A0A0D8XLR1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=DICVIV_08483 {ECO:0000313|EMBL:KJH45480.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH45480.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH45480.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH45480.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; KN716406; KJH45480.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8XLR1; -.
DR STRING; 29172.A0A0D8XLR1; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR044635; UBP14-like.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR43982; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR43982:SF6; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:KJH45480.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766}.
FT DOMAIN 198..667
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1172 AA; 132736 MW; CEBAB4B0422EE367 CRC64;
MSQKAQPSLF ASVKSPPDYG AKSTTPLATG GGPTVEEQCT IEHIRSFLGS SDFDEDLCLK
AVRHPRLRSQ KTSNEEEYLQ EVVGVYMDEM NNVTRKEHQR SQTPRPVQGC PTPQIRTIAE
LTAETSHRSA GQTVPVSSSG PTTYTTTPMI LDHPSAVEER ELAIAESLIS QGPSGSRSYA
SSLPSNPEEL LRKEGVSVGL HNTGNTCWFN VVAQLLFHLP RFRRIVYEQV PRYSQLEYKG
TAQKTELMEM DLVQQMCYLF ACMDVGNKRY VDPSEALKVV SALAARNKSD VIVGRQQDAS
EMMSNLMEWM EKGLSSFSSL PEKIEDLHAK ELSVESNHSL KSTEISPPVS IEEGCDGMDT
TNSQPFSDIA HFWNKLEYTS LFPVQVSHGN LHDALEAHQF LNDSGKEPWF ESLPAVLIFS
LGRYFFNGSK GETEKLNMRF HFPRTIFMDR YMARNYECVT IIRDKRNLLR KELANVRAEL
KGFNEFPIGD HTDKVTNVLK AALHFVKGHL DQSEVMDDDS KTAPLSSSAT TGKLHSFVED
KPPVIPISSH FQHFSEFVGD LENSIIELEE KHNKLCVHEA ELIKMIDEIY DIDGLKQHKY
QLHAVAIHQG HANAGHYWAY VRKGNDDSQW EKFNDQRVDC ATWSDIETEA IGGTRTTSAY
FLLYVSSAAE PWLFSSDSVV SSFLKNDIRR QVEDENAHLD SEVERYRCTQ NEDGKGNVDS
HEAPCDSRLS VPPPPIRFCR RLFMTFFKAV SDPANLGISL KMYCDPLFDE SALEVEYKKL
FSLLEFNKMT YPPTVNRDTV IENQAKLMCR SVLKPMFVAL VRRSEAAGNL AKSSEIYNKL
ISHFYDDFDN LSCSMQSPPL RCLPDFCYAM GFRVPAKMIR FAILRALIHA DSEEIVKHAR
AELEDFNSAP FADHYVVLFQ HASHLFDLVK ILWNVVRQVA TDMNHNNTSN VLRLSWKTIE
INFKILKMVS AVTNIYERLY VELGNIQGTE YQAHSDFIIP SFIIRGINII PILGVFATIV
EYLVDRTNPR EEIARLLTES LTWVELIVHR LATWARNGCK DAEKVISHIN ETLNMIALVF
QSSAAPIKRE ISRRIHGATQ LDRHFESPVQ AFISQATDLC HEIEQANYQL SLLGLTDHAE
ADNVYTRMMA VVSDIINNAM LADERTSFSV DF
//