ID A0A0D8Y294_DICVI Unreviewed; 704 AA.
AC A0A0D8Y294;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=DICVIV_03560 {ECO:0000313|EMBL:KJH50277.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH50277.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH50277.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH50277.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm,
CC perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR EMBL; KN716210; KJH50277.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8Y294; -.
DR STRING; 29172.A0A0D8Y294; -.
DR MEROPS; C67.A02; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR11830; 40S RIBOSOMAL PROTEIN S3A; 1.
DR PANTHER; PTHR11830:SF3; CYLINDROMATOSIS, ISOFORM D; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 168..225
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT DOMAIN 393..704
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 99..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 78878 MW; 57FE143549B77F1D CRC64;
MNGSGWSNSR CFYVDAGQLY NSRSSTIAEN REILSSKPRV IPIRRLNTGH EPQREISSSA
IESYGNKLMS WNGGRFDVRQ ESNLFDTYDD YDVGHILERE QHKDRETRHR NRPQNIAPTR
SQSSHAVVVH DRTYRVDDPA STGGVVVGDR CAWISDGVVY KGTIKFIGHL KGHSSLYAGI
DFDDKVGKGT GVFQGEVLFE TPENHAGFVL LSALQITPRS SSFIGNSGSR YASIVQKQAS
AESLHDIAYP PVPPRPTKQA EDYMINSFSV GSCVEVCHLG ACRSGVVRWV GDAMSQDHDR
IEMSAVVELD NFSPTGWRPA YEAPISSAAN LVNGVLVPMS ALRRDRRIEK CSSSESRRSP
IQVRTDFGSI DSGVEPMKCD PWRITDDLIG RMKGIQGHRN SCYLDATLYA MFVQSTAFDK
LLDRPANKDD IPQYREFQCL LATEVVYPLR KFHYVRADHI MKVRELLAKA LPDMRGLTSE
EKDPEEVLTA LFSKLLRAPP LVELINLKDN NVDRTYLCPL IVDDWAAGVA TTQHLLDRSI
RSANVKFAFP PKTLILQLPR YGQQKLFDKI LPLEHIEITG LVNNSIQACY GCGKPAEGMC
PECFLCKKVT LSEVSYCVPC STRVHCNAGE QDHAIRLFYP SSQPLKKPSL HRMILSAVLC
IETSHYVAFV RSLSGRWLFF DSMADREGFS DGFNVPQVRM LCSF
//
