ID A0A0D8Y5N6_DICVI Unreviewed; 439 AA.
AC A0A0D8Y5N6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
GN ORFNames=DICVIV_03987 {ECO:0000313|EMBL:KJH49876.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH49876.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH49876.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH49876.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC {ECO:0000256|RuleBase:RU368069}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC ECO:0000256|RuleBase:RU368069}.
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DR EMBL; KN716221; KJH49876.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8Y5N6; -.
DR STRING; 29172.A0A0D8Y5N6; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR InterPro; IPR005365; Npr3.
DR PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR Pfam; PF03666; NPR3; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU368069};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Signal {ECO:0000256|RuleBase:RU368069}.
SQ SEQUENCE 439 AA; 49325 MW; F9B11A244E37422E CRC64;
MDRTASHLIN NLKNLYYMRN KSTRNLAKST ESAVNTLVDS ISKTDRDPRN TKKSGEMSFA
TQFILSTCML ANILSVRDSV DAPFELKVDN VRFAGHPKKL TTASEGSSTI FSIVFVLPAN
VDSNLVESFQ LTTASEGSST IFSIVFVLPA NVDSNLVESF QLLSKKLALA IDSLQTQRGY
FAEQERVMRS ALDEFEAEVS ALPESDQLAF DVPWESIRRR SALAELLTKV FIDVGRTGVV
QVFVDNFIEV GFCVQSRAFT HAHLTPKNRA EIDKIVKKIR PYHGILLLED VWPSPDANPS
VTLLLKHCEP DRSILDISTA SGIPLLQVFL IVRHLLLWAR AVVIYPLCNT NVYSSATHPK
PLERYISLFC QQFGSKFHLS DVLSQFDPPR SLGEYLNSRQ PLFDQQNKAK VIVALLRHQL
IMQRSGYHFK IETGGPFWL
//
