ID A0A0D8Y977_DICVI Unreviewed; 569 AA.
AC A0A0D8Y977;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=SH2 domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DICVIV_00586 {ECO:0000313|EMBL:KJH53275.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH53275.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH53275.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH53275.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ADIPOR family.
CC {ECO:0000256|ARBA:ARBA00007018}.
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DR EMBL; KN716154; KJH53275.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8Y977; -.
DR STRING; 29172.A0A0D8Y977; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR20855; ADIPOR/PROGESTIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR20855:SF3; LD03007P; 1.
DR Pfam; PF03006; HlyIII; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 62..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 252..387
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 477..567
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 429..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..449
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 64831 MW; B377D2EE97CE9570 CRC64;
MSGSCGIESP SLYKNKRATK SEAYEPTTYE HWANTVSHAV AIVPSVVVFR HMIAKSHGYL
QFYLMVIYGL FTTLLFLFST CYHACDLMYR QRRIQRRLRY YLHICDRAAI FLFIAASYTP
WLTLRHCGYP GLNLKWMVWV FALLGILYQY NFHEKYKDLE IVIYILIAGC PSVAVFSMND
RNGLEWMILG GIIYITGVLF FKMDGIIPFA HAIWHVFVLG VYENDEKNLF ILFLTSLAEA
MALPPTAAEL RGSGIQFTFK YLGSVPVMVA LHEMTEDMRP LVVKECINII AGESGIIPVR
ETNAIIKLLV GKPDLANHQV ELNISTKALT IIYSDDRNKE KMNRMVARHN IELVSFAAQG
SEETNTADMF GYIAKRRDET DRRCYIFRFN DVPRVMHIID DAIRLATRDM PKVSPTPLKS
EIAKAESPFV HELRPQPLAP SPRPANWSRI PDRPSPELGV RDDPNGVLGL DLQDKPWFHG
ELDRAAAEYL LQRDGDFLVR TSANSPGQFI LDGKEQGNYR HILLINDGVV RTMNNIFPSV
SALITYHYGN HLPILTQESV IYLTNPILK
//