ID A0A0D8ZN88_9CYAN Unreviewed; 1090 AA.
AC A0A0D8ZN88;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=UH38_19630 {ECO:0000313|EMBL:KJH70205.1};
OS Aliterella atlantica CENA595.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Chroococcidiopsidales;
OC Aliterellaceae; Aliterella.
OX NCBI_TaxID=1618023 {ECO:0000313|EMBL:KJH70205.1, ECO:0000313|Proteomes:UP000032452};
RN [1] {ECO:0000313|EMBL:KJH70205.1, ECO:0000313|Proteomes:UP000032452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CENA595 {ECO:0000313|EMBL:KJH70205.1,
RC ECO:0000313|Proteomes:UP000032452};
RA Rigonato J., Alvarenga D.O., Branco L.H., Varani A.M., Brandini F.P.,
RA Fiore M.F.;
RT "Draft genome of a novel marine cyanobacterium (Chroococcales) isolated
RT from South Atlantic Ocean.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJH70205.1}.
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DR EMBL; JYON01000026; KJH70205.1; -; Genomic_DNA.
DR RefSeq; WP_045056389.1; NZ_JYON01000026.1.
DR AlphaFoldDB; A0A0D8ZN88; -.
DR STRING; 1618023.UH38_19630; -.
DR REBASE; 113172; Ccy595ORF19630P.
DR PATRIC; fig|1618023.3.peg.1940; -.
DR OrthoDB; 9758243at2; -.
DR Proteomes; UP000032452; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KJH70205.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000032452};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KJH70205.1}.
FT DOMAIN 333..539
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 739..1078
FT /note="Type ISP restriction-modification enzyme LLaBIII C-
FT terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF18135"
SQ SEQUENCE 1090 AA; 125228 MW; 9FEE684A458170BD CRC64;
MTFTKQLSRA LMTGTNEERV EELRKILKYP VQQKDPGGSR FYYLHPGEDE AEARDTCPIA
VGFYSELNDA TDGEIRSFLT AGEPQPEIYK HYTSRVSEDQ PVMYLLLPAK EGAGRVPLVL
PNEGGLRSRQ IQTFDWNEPE LLARLRRLEQ GVLPIATRAL CSVPLVEGVF YDPIKTAKEL
ARSLAEVARK IEKAIPTVYD AEKKDGYLHK LLKNFQRDLL PNLQATPHNE KDYSFADIYA
QTIAYGLFTA RVFNHVKDER EGKAKETDFN RQDAWKQLPE TNPFLRKLFR EISEQKSQEL
GKELIEAIAD IFIILRKTKM DAILSDFRQK MNQEDIVIRF YEDFLKAYKP EMRELRGVYY
TPEPIVSYIV RSVDSILKAD FGLEDGLVDA TKVQVKTKDG KNTKETHKVL ITDVAIGTGT
FLHSVIDHIH KSFKPSQQLT WSDYVSQHLL PRLSGFELLM APYAVAHMKL GLQLAELGYK
FDTDERLRVY LTNALQEAFQ IPPADGFDNW IRDEADAANI IKQEAPVMVL LGNPPYSGHS
ANNGTWISNL LKGKDTITSQ ETSSYFEVDG KPLGEKNPKW LNDDYVKFIR FSQWRIEQTG
YGILAFVTNH GYLDNPTFRG MRQSLMETFD DIYVLDLHGN SKKKERCPDG SKDENVFDIQ
QGVSINIFVK HPNGKKENAT VHHANLWGVQ ECKYNWLKEN DINTTQWTTL QPQSPFYLFV
PQNNDLLAEY QDGLKITEAM STNGWGIATR KDYLLTDFTV ESLTQRMSIV VNGTLDEAYQ
EGVKDNESWS FSKIKNRLGS DIKSRVYSYY YRPFDYRYIF YEPLMIERGD HRLPIAKNFI
HERNNLSLLI SRTGAASGSP IWDVMFVGDS LSDLNLFRRG GAFIFPLYLY PDTDNLHQST
TAEQRRPNFS EDFLNAIKDK LGYIPTPEAI FYYIYAIFHS PTYRTRYAEF LKIDFPRVPL
TSCDRLFRQL ATYGEELVAL HLMKSPKLDN LITQFVEGRG DRLVDAGHPK FSQGEVVINK
KGDKFTGVPE NVWNFHVGGY QVCQKWLKDR KGRTLSDEDI LHYQKIVVSL QETIEIMEKI
DAAIPGFPIQ
//
