ID A0A0D9MWU5_ASPFA Unreviewed; 902 AA.
AC A0A0D9MWU5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Rad4 family protein {ECO:0000313|EMBL:KJJ32362.1};
GN ORFNames=AFLA70_67g003380 {ECO:0000313|EMBL:KJJ32362.1};
OS Aspergillus flavus (strain ATCC MYA-384 / AF70).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1392242 {ECO:0000313|EMBL:KJJ32362.1, ECO:0000313|Proteomes:UP000032444};
RN [1] {ECO:0000313|Proteomes:UP000032444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-384 / AF70 {ECO:0000313|Proteomes:UP000032444};
RA Yu J., Fedorova N., Yin Y., Losada L., Zafar N., Taujale R., Ehrlich K.C.,
RA Bhatnagar D., Cleveland T.E., Bennett J.W., Nierman W.C.;
RT "Draft genome sequence of Aspergillus flavus AF70.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJJ32362.1}.
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DR EMBL; JZDT01000518; KJJ32362.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D9MWU5; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000032444; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.60.290; Rad4, beta-hairpin domain BHD2; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 522..579
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 581..644
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 651..725
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..73
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..779
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 101431 MW; 6A5461E56CCED1AE CRC64;
MPPFVPRKRL SSADPPSAKR HNATAAPSVD IAALDDESDS PLSDVPSEAA LQGQDLEDEA
SDESESDDDE VDWEDAMDSK ATTATATTPS MTPAHVQDLE LTLDKNEVHL SDIIDGKKAP
SKIERQIRVL THCLHVQFLL HHNAIRNAWA NDSQVHDILR RKLPEALYKE VKKWKVSSGL
ELPEKPPEET TKKKKWKQRR KSERDWGEGS SRMEPGQPDM SRGDPIITLL KVLAAYWKKQ
FKITAPGLRK RGYRPMSHLE ADISAFNKEE HDPERFGEKV CGIEEFRQAA ERMEGSRDLG
AQLFTALLRA LSIEARLVAS LQPLGFGWTK AETYTPKVKV EAEAQTEIGD TEDADSDDSD
VVQKPVGSRT NPKGYDKDLP VPIYWTEVAS PVTHQIIPVD PLVLPNAVAT TPELQAAFEP
RGAKAEKAKQ VICYVIAYSS DKTAKDVTTR YLRRRTWPGK TKGYRMPVEK IPVPGRRGKF
HEYNWFRVIL RIYERSTKSR TAVDDLEDAN DLVPNQPEKK SAKEGDTLQS LKASTEFVLE
RFLRREEALK PGSQHVRTFV SGKGIKAKEE KIYRRADVLK CLSAESWHKE GRQIKKGEAP
LKRVPIRAVT LLRKREVDEL ERETGEKPKQ GLYAKYQTEY IIPPPIRNGV IPKNDYGNID
CFVPSMVPRG ATHIPWPGTV RICKKLGIDY AEAVTGFEFG SKMAVPVIEG VVIASENEDL
VKDAWRADAA EKREKERRKA EARILQTWRK FLFGLRIAER VREEYGESSR DHERDAYNPF
TSRKSGQQAP APEPHVREPS EEGDPVDYGG GFLLPGEDDG DDGDLIVERH QPSQPERENE
VAAAAESDDA AVMEMKISDT SSVQELSSSP EIADSEDELP DSEPEYVPPA TRRRTRNATR
KG
//
