ID A0A0D9NWN0_METAN Unreviewed; 2410 AA.
AC A0A0D9NWN0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KJK77000.1};
GN ORFNames=H634G_08042 {ECO:0000313|EMBL:KJK77000.1};
OS Metarhizium anisopliae BRIP 53293.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=1291518 {ECO:0000313|EMBL:KJK77000.1, ECO:0000313|Proteomes:UP000054544};
RN [1] {ECO:0000313|Proteomes:UP000054544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRIP 53293 {ECO:0000313|Proteomes:UP000054544};
RX PubMed=25102932; DOI=10.1186/1471-2164-15-660;
RA Pattemore J.A., Hane J.K., Williams A.H., Wilson B.A., Stodart B.J.,
RA Ash G.J.;
RT "The genome sequence of the biocontrol fungus Metarhizium anisopliae and
RT comparative genomics of Metarhizium species.";
RL BMC Genomics 15:660-660(2014).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE384742; KJK77000.1; -; Genomic_DNA.
DR STRING; 1291518.A0A0D9NWN0; -.
DR Proteomes; UP000054544; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF18; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054544};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 64..492
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2327..2408
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2410 AA; 261696 MW; 1B66F66CD98B7364 CRC64;
MTQVTDIHPS LPNGINGHMG HGSHNGSYPS NNSNHTNGTN GHGLLDAGAT KSNGHGPRAD
PNVQTPVAIV SMACRLPDQC HNPQQFWQFL LDGKIAINTP PGTRYELATH YDGSLKSQTM
ASPGGMFLQG VDPADIDAKF FRLSGVEATS MDPQQRQLLE VVYEGLENAG VTMEQLDGAR
VGCFVSSFAS DYGDMQARDP ENRASATVVG VGRTMLSNRI SHSFNLKGPS MTIDTACSGT
LIGLDLAMKY LHTGEIESAV VAGANLYCSP EHVMDHYMGA NGAASLTGKC HTFDAKADGY
IKAEAVNMIY VKRLEDAIRD KDPIRAVVRG TATNSDGWTA GIASPNPVAQ SAAIRQAYKN
AGIRDLSKTS YVEFHGTGTR AGDSIEASGI ADVFAEFQSP DRPLRIGSVK SNIGHSEPAA
GLSGLIKTVL SLEHDVIPGN PTFIDPSPKI DFEKLRIWTS RTATPWPALP LRRASVNSFG
YGGSNAHAIV DEAKGFPRHH VSSYDDQSRR SLVEEEQVDQ RQRIMVLSAN SEKSLQDQFS
ALDKHLSNPG VVVKQRDLAY TLSERRSRHY YRGFVLASDH YLDAEAFETD RMRDEPLSIA
FIFTGQGAQW PEMGRELLAS FPVAAKTVRH LDDVLQSSYG APAWTLYDEL TSPRSADHMR
LPEMSQPLVT ALQLAILSIF DAAGVSCRAV AGHSSGEIAA AVAAGLLTPE QAIKIAFYRG
KATSAVKHGS PLGMMAVGMG PDAALEYLDG SSVQIACFNS PQSITVSGLR SELEPMEQRI
KDDGHFARLL QVDSAYHSRY MNAAAGAYRE LLDKHVEWET RPAPKGKIMF SSTTNKMLAE
SPGADYWVKN MLSPVLFSQA VTSMVRAESS DINYLVEIGP NNALSGPVNQ IQKAAATSLD
YSSAWKRGAG AMQTLLECAG KLFNAGSAMS LSPFNDDGLP VPPTFVLDLP NYQWDHSTKY
WHESESSSDW RFRKFVHHDL LGSKILGTPW TRPIWKNFLR VSDVTWLKDH TLGDSIIFPA
AGYMAMAIEA MYQKSKALGA IADDATVVDQ TYKLRNVAFP RMLTLNEHAG TKLVLSLEPC
SSTKETWHEF TISSIPKDGN GALEEHCTGL VSVGHDVRHV AATADDVSPL KFGVPGSVWY
KAMRDVGYFF GPAFQPCESI EAKADARNCR AVIKLETPSS RYPQSRYAMH PTAIDGCLQI
ATVALNRGHR SALDTMMPPR LIDNLVIFPQ PDHVERGIVA SEAMWSGVGR PDDNKRFYSD
IRTYAQGSNE ALFHLQGLRY HSIGASADAP HVFTQVQWAE DAGFLTPEQL STVMASDEEA
PPMAAVAKAV SIMAHKKPTS KILEVVYRDG EAAVHSLWLD GLRQLSGPIA EGCAYALSAP
AHTTSLALRE KYSTEANVTH VVHESDCITA GVDGDDEDDK IDVVILRAPA ITPDLIKAVE
GARQAIADGG YLIVVKDDVT DGKTDQANEV VEASVPGFNA LKLSGNCVSD VIFFGIASDS
ASQVQDSADK TVNLVRFTTS NHSTAAARGA IAKQGWQIVE KGLSLGGIED KSTVIVLDEM
FSPVLADLQD EQFDALRGLL ERECKILWVT RGSQMTVRTP ELGLMFGASR SLKAEYPQSV
FVCLDVEAND SHASFGAIDR VLKHLGTLTD VSKVDSEFVE RQGVLYISRV ISDAAVNKAE
HDSQHGADKV NGIIGGHQST IRLISDRTGT LDTLTYTEIP EVPALKDDEV EIEVRAAGMN
FKDLANAMGF VPANERLFGL ECTGVVTEVG KDVSTVKPGD RVLMVRRDGG CFGNKVRNRW
HAVYLLEDDM SFEEGTTFGI AVHTAVYGLV TMANIQKGHS VLIHSASGGV GLAAIDLCKY
IGAEIYVTVG TEAKRDFLAQ NYGIPRDRMF SSRSVSFGPE LMRATGGRGV DFCLNSLTGD
LLHESWRCIA ENGSLIEIGK KDMLDRNTLS MEPFDRNCSY RPLDLSRPSI TDETTRKTGE
YIMDLIAKKH IKPLHICKVF PFEQTAEAFR FMQRGKQIGK VVISYEKART TEIEYRPAAP
QLRLRPDGSY LIAGGFKGLC GSLAVYLARS GAKNIVVISR SGYDDEKSQK TVYDCNSLGC
SVDLVTGDIT KLDDVRRAFA SASKPVVGVI QGAMVLRDRM FTTMTPGEFR EPISPKVDGT
WNLHKASLEQ PTPLDFFTML SSVSGLLGQL GQSNYAAGNC FLDSFAAYRI QQGLPANAIN
LGPVEEVGYL KDKDMLSRIF ESRGWKPINE ALLHRIIRSS ILLQTNTINP AQAGQLITAI
TPGNPPFEAV HRFSSLRPVA GTLAGSGGTA SSASSKLAIL KSAGKGDVAR ETLLAAATEL
LNTVLMRSLG IDESIEPMRL LANYGVDSLV AVELRNWLRA ELNVEFSALE IVGSRTLTTL
SESILKKLVH
//
