ID A0A0D9NXI1_METAN Unreviewed; 648 AA.
AC A0A0D9NXI1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN ORFNames=H634G_06219 {ECO:0000313|EMBL:KJK78521.1};
OS Metarhizium anisopliae BRIP 53293.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=1291518 {ECO:0000313|EMBL:KJK78521.1, ECO:0000313|Proteomes:UP000054544};
RN [1] {ECO:0000313|Proteomes:UP000054544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRIP 53293 {ECO:0000313|Proteomes:UP000054544};
RX PubMed=25102932; DOI=10.1186/1471-2164-15-660;
RA Pattemore J.A., Hane J.K., Williams A.H., Wilson B.A., Stodart B.J.,
RA Ash G.J.;
RT "The genome sequence of the biocontrol fungus Metarhizium anisopliae and
RT comparative genomics of Metarhizium species.";
RL BMC Genomics 15:660-660(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
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DR EMBL; KE384734; KJK78521.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D9NXI1; -.
DR STRING; 1291518.A0A0D9NXI1; -.
DR Proteomes; UP000054544; Unassembled WGS sequence.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd08598; PI-PLC1c_yeast; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF82; PHOSPHOINOSITIDE PHOSPHOLIPASE C; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW Reference proteome {ECO:0000313|Proteomes:UP000054544};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT DOMAIN 362..475
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT DOMAIN 474..619
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 150..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 71491 MW; 6B2F6B0C9C127F2A CRC64;
MAALQQAGGG ASQAQRAPPT LTNTVISYLK TIFESHADAD GRWTLGQIAR FIQQVQKNSD
KTTAAAKLLQ STEIDLSAFL QYMTSEDSNI TEPWNQSDLS WPLSSYFISS SHNTYLSGNQ
LYSDSTTDAY TNVLLRGCRC VEIDVWDGDE SDLSASSTES SADEKADDEA VPTKSKRHGT
FDRLRQRIPD SLTSKLEKTS LAKTLELKHT GKHNTDTANG ALPDGDSKIV PEVALVEPRV
LHGYTLTKEV SFRDVCNAIR DSAFTVSDLP LIISLEVHCG AEQQVMMANI MKQVWSGMLV
TEDEIKPGLL PSPEDLKRKI LIKVKYAPPD TPAAEPDSSA EDDSSPAEAA PPKKPSKVVQ
ALSKLGIYTR AVSFKTWTQP EASMPTHIFS LAEKKFIEHR EKHAQALFDH NRDYLLRAYP
SGLRITSSNM MPTVFWGSGA QVVALNWQQT DEGMMLNEGM FAGTCGYVLK PEGYRPNLPS
KPTPNKITYK TLNLSLTFLA AQSIPLPHGD KSDKRFHPYV KTELHVDACN APAHGRPGSS
ESLDTDVRHK ARTKTHKGTD VDLGRQQVSF NGIDGLVEEL TFVRFTVRDD ELGRDDLAAW
ACVRLDRLGQ GYRFIHLIDS KGHLTDGTIL VKVEKTLVEE KPDGKEGA
//
