ID   A0A0D9NY44_METAN        Unreviewed;       860 AA.
AC   A0A0D9NY44;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN   ORFNames=H634G_05542 {ECO:0000313|EMBL:KJK78728.1};
OS   Metarhizium anisopliae BRIP 53293.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=1291518 {ECO:0000313|EMBL:KJK78728.1, ECO:0000313|Proteomes:UP000054544};
RN   [1] {ECO:0000313|Proteomes:UP000054544}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRIP 53293 {ECO:0000313|Proteomes:UP000054544};
RX   PubMed=25102932; DOI=10.1186/1471-2164-15-660;
RA   Pattemore J.A., Hane J.K., Williams A.H., Wilson B.A., Stodart B.J.,
RA   Ash G.J.;
RT   "The genome sequence of the biocontrol fungus Metarhizium anisopliae and
RT   comparative genomics of Metarhizium species.";
RL   BMC Genomics 15:660-660(2014).
CC   -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KE384732; KJK78728.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D9NY44; -.
DR   STRING; 1291518.A0A0D9NY44; -.
DR   Proteomes; UP000054544; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR044554; APC2-like.
DR   InterPro; IPR014786; APC2_C.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF08672; ANAPC2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   SMART; SM01013; APC2; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054544};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          530..735
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          754..790
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   860 AA;  96372 MW;  D8EA649A03E4A4C9 CRC64;
     MTASRVRARK SKVLRSVFQT DVSQPTPLLL PTVPGEPFGG PLASSTSTTR LANISSLQTV
     SDQVRWDRAW HTVTSRIQLP ASVAVEDSFG TLPAESQDRD ASFYESLALL LGAPTALPRA
     THTEDVLLWH THQVRQHFVH HVLPLLAACA AQGDHAQVLL SSVQTLEAAH RQYLYGLTLI
     VRGLEDEAAK SLVVDKFKRD LHAIIGNSWA RGLAEALRGV LSRLLALILG SNRNVLASGA
     GHRDEGRMDT ARNELLSLLE SLDNVGLAGD KFQVLFAEIM DECMSDFIRR TYTGVWTALD
     VAGNVNPSAS SGCMAHLCGW VENHYGRLAV EVFSRLGGRV AWTDVERWRD IAVGRLASLR
     IKELFDVVLH WPESKGGLED LRSAVATPQR RLQLTDTFSA TLQKRLLHPG RSTLDILQTY
     ISMIRTFHQL DSSKVLLDRV VHALQLYLCQ RDDAIRIVVT GLLSNPDSVD SDESKQRLVE
     LAVLLNEASQ QQRSHVDDED LDWDDMAWVP DPVDAGPNYK RPKNEDVIGT LINALGSQEI
     FIKEFQMIIA ERLLSNQAGF QQEIKVLSLL KKRFGESALQ NCDVMVKDVY DSRRVDALLR
     KNLPSTDGQQ ANHPRPVNYH SKILSRLFWP SLPKTPFTVP APVAEIQRKY EAGFEQLKTC
     RKLTWLDHLG MATVRLDLDD RTLEQECKTY EAAVIYAFQD DEGLAHGPQQ RTFNTLWEKL
     KIDEDLLESA LRFWVSKRVL REVGNQTYEV LEKLDQDESA NAGDDAGSAD EAVKTSQPSP
     RKPKMDPKEQ ERRTVYWQFI VGMLTNSSPA MPLGQIAMMM KMLIADGCPW NNEELQEFLG
     EKIAEGELEL SGGKYRLVKK
//