ID A0A0D9P789_METAN Unreviewed; 1507 AA.
AC A0A0D9P789;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=H634G_03272 {ECO:0000313|EMBL:KJK82008.1};
OS Metarhizium anisopliae BRIP 53293.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=1291518 {ECO:0000313|EMBL:KJK82008.1, ECO:0000313|Proteomes:UP000054544};
RN [1] {ECO:0000313|Proteomes:UP000054544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BRIP 53293 {ECO:0000313|Proteomes:UP000054544};
RX PubMed=25102932; DOI=10.1186/1471-2164-15-660;
RA Pattemore J.A., Hane J.K., Williams A.H., Wilson B.A., Stodart B.J.,
RA Ash G.J.;
RT "The genome sequence of the biocontrol fungus Metarhizium anisopliae and
RT comparative genomics of Metarhizium species.";
RL BMC Genomics 15:660-660(2014).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR EMBL; KE384725; KJK82008.1; -; Genomic_DNA.
DR STRING; 1291518.A0A0D9P789; -.
DR Proteomes; UP000054544; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000054544};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 8..377
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1011..1183
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1192..1496
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 97..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1359..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1507 AA; 164056 MW; 4D60772A74F96E70 CRC64;
MDAAEYDTNI LVVNNIASIS FRVYEPSSDQ SSSFGLAAID IENSLREKGH IVYYDASRRG
IWHFRIVGKE GSDEVSSQEL DSSLSLRGYS LIVGEEGSFE PSSLPRPRSQ QPQTGHTPTS
STSSASALDQ SQRYAPTATS HLGPPGLQEQ DSKGYTSVTD AKLVQGGSSS PKAYESFVVA
TLLTIQSAFC RHTDSIPLNY RTVLLSQDIL ENDGSFDVLT EKTPTIGTFS AYLTTTGVLV
VCMGISICRG SLSYGDMLNQ APDIPGQQIL AAPFGVIASN QPAAQFDGGT ASMAQTPNTQ
ALSLRGAPDI HNSLWKQACL KFLQLRGVAQ SKLTDCFWIN LLISKPKLQD AKSDVKRSPM
PNSTVTIPWP SPLCFRKRPV EVSSTSRVGE TILRGHEESH DPLGNAQSWF SSTPERDEKI
SKRKAERVAT SSEGFGGDSR PTRLNGQSPL TLRRPSTAAA GSMYPTPPDA LQNANGVTPS
LDGTLSSPGN PLSAAAVPEV DNNGSVSMAM GDSFEPVRDF SESKRQRSDS NLLGEADHMF
GDMGQDMFGD NDITEADFNF FDEEPEDIDL EAALDEMGDA TTAAIIGAEE HTADEEISNS
REPIKEEPET EKDAGGFTKP ELCHAISVQN NHAMPRGRES RPVSMKRESS PFDPHTVFKR
VCASLAATEK DGTIATDASR MTKIFEKMDF DPTLPMINKK YEQGGQFDYS MSTAVGNSRL
DHGVLPETDY LKRHGKLHRG SQEHKLYTKS LMGPLSGLER PISGRSPTKL DTQMSDDEQS
STESDQDDSS YTSDEPTSPP KSSVKQAPVE EDAVSQVTSL KEQDVIEEPD HQLAIELPRL
SKPETPELPL SMLFSDPEPL ALELSLGDED LIQAAQILTE QAATGSLDLC NTDRPANTSI
ISQGRATLLS DSRTALQQLR EALSVFLRGV EPVRLKAFLD IQDVLLQGQP RMQPRPIPGR
DANAEQIRPS NLYQIPGPHL EVRRSDAKLS VLPSAVAFWE SLGLAPSSGS KDITAVCVFP
GWKGMADNVK TFLGRIKSVY EVLRLGSFEN MALASDMDSG VLPYEMDRIS TSPDATLTGH
GSALIGTMET LRASLSNLTV SDTNVVVYFV YSPNNPGTIV EACAAFQRFF DSYQKDLAAK
KETATNELVL QLVSSDLLSS PTSVVVTPSV DLVRLCMETY DRCTLFGGPM PAPAIRLEQP
LPRIIDFKLN TQPSMSLIRE NSCIHVAYAQ TVDGRWVTTA WTDDRGNQQA TASYCLGRKG
RPLSTSMSEV AYEIWQSTLD LISAWTVHWR VIITKCGPMD QQEIDSWVNL AHTETRLQVT
MILMTVDTDP WLQLVPPVVK LPHASVPFYT TPVSTPQANI VSPEQSATPA TPANLTAATP
GGGEAGADTE TDAILADVTD QTWGAIVGHR LNNSLGVTDL YPALVSGFLI KRTGARAEDV
PIAMEVNLIH TEAFPRSYEP LLREMLSYFR GLATLSRARG MVSRETDVRP WHIAAAEKAS
RAMYLLM
//
