ID A0A0D9QE95_PLAFR Unreviewed; 305 AA.
AC A0A0D9QE95;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=F-actin-capping protein subunit alpha {ECO:0000256|RuleBase:RU365077};
GN ORFNames=AK88_05025 {ECO:0000313|EMBL:KJP85323.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP85323.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP85323.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner
CC to the fast growing ends of actin filaments (barbed end) thereby
CC blocking the exchange of subunits at these ends. Unlike other capping
CC proteins (such as gelsolin and severin), these proteins do not sever
CC actin filaments. {ECO:0000256|RuleBase:RU365077}.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC {ECO:0000256|RuleBase:RU365077}.
CC -!- SIMILARITY: Belongs to the F-actin-capping protein alpha subunit
CC family. {ECO:0000256|RuleBase:RU365077}.
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DR EMBL; KQ001732; KJP85323.1; -; Genomic_DNA.
DR RefSeq; XP_012338052.1; XM_012482629.1.
DR AlphaFoldDB; A0A0D9QE95; -.
DR EnsemblProtists; KJP85323; KJP85323; AK88_05025.
DR GeneID; 24270339; -.
DR VEuPathDB; PlasmoDB:AK88_05025; -.
DR OMA; VACIEDH; -.
DR OrthoDB; 179910at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0008290; C:F-actin capping protein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0051016; P:barbed-end actin filament capping; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1140.60; F-actin capping protein, alpha subunit; 1.
DR Gene3D; 3.90.1150.210; F-actin capping protein, beta subunit; 1.
DR InterPro; IPR002189; CapZ_alpha.
DR InterPro; IPR037282; CapZ_alpha/beta.
DR InterPro; IPR042276; CapZ_alpha/beta_2.
DR InterPro; IPR042489; CapZ_alpha_1.
DR PANTHER; PTHR10653; F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10653:SF0; F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA; 1.
DR Pfam; PF01267; F-actin_cap_A; 1.
DR SUPFAM; SSF90096; Subunits of heterodimeric actin filament capping protein Capz; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|RuleBase:RU365077};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|RuleBase:RU365077}.
SQ SEQUENCE 305 AA; 35038 MW; 4A76AAC7F7F7BC68 CRC64;
MESLLNEKKN FIRHVLMHAP PGNLADLVSD LKTLFGTSAA IQNTIEEAVA AHNEKNYAII
PLSGDDYVIT CEESKVGNSY LQPKLKSLLD VNHLKKKVNT TADVEEVRYP DLLENYRNSC
SAKLEEYVQV HYSNWNELQT INYPTVNINS KNGLSVKCCS SVYAKEHEGR FNLLFVVCCD
RHYLKNFHAS SWRSSWNVTF LTTDEEVLLN GTIDIVLTYF EDANINFKAT KRFEKRVHVN
SAVDNFSANI VSAIRECENS ALYELNEFLI HIDKELIKNT RKIMPFNGDK FDWKETYHDI
PSQIK
//
