ID A0A0D9QEP4_PLAFR Unreviewed; 1856 AA.
AC A0A0D9QEP4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=SF4 helicase domain-containing protein {ECO:0000259|PROSITE:PS51199};
GN ORFNames=AK88_04903 {ECO:0000313|EMBL:KJP85464.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP85464.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP85464.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ001724; KJP85464.1; -; Genomic_DNA.
DR RefSeq; XP_012337930.1; XM_012482507.1.
DR EnsemblProtists; KJP85464; KJP85464; AK88_04903.
DR GeneID; 24270217; -.
DR VEuPathDB; PlasmoDB:AK88_04903; -.
DR OMA; HECLIFP; -.
DR OrthoDB; 9502at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08639; DNA_pol_A_Aquificae_like; 1.
DR CDD; cd01029; TOPRIM_primases; 1.
DR CDD; cd01122; Twinkle_C; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR034154; TOPRIM_DnaG/twinkle.
DR InterPro; IPR027032; Twinkle-like.
DR PANTHER; PTHR12873; T7-LIKE MITOCHONDRIAL DNA HELICASE; 1.
DR PANTHER; PTHR12873:SF0; TWINKLE MTDNA HELICASE; 1.
DR Pfam; PF13481; AAA_25; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56731; DNA primase core; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1856
FT /note="SF4 helicase domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002343375"
FT DOMAIN 590..839
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
FT REGION 61..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1493..1534
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 486..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1191..1214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1856 AA; 212534 MW; 3E0D47FE945E1752 CRC64;
MVRCQIFLFY LILIHYVLAL RNKSRPKTDF YLKTNCELVK RRKNGSKPYF KRKSRDEDLG
SRACYSPLRG GRSNGRSGDN RRNNNSGALH ATSTFVSKYY KININDVYSY LNRKKYEYIE
TDVKITLKYC PFCPPHKYKY DNMYKHEIFK NTGNSYCHRC GYKGSFYDFK LKMGDLVTSN
FESTVVSSTY EEEKITFNDV KVYNMNLLYS KEAEAARKYL IEDRKLTLET LKKYYIGFSI
MEFQSLENSG KFEKHECLIF PFIKKANDMN SMGLNGNKNH TNEKDSYEIV RIKVRSLRDK
GYMRLYPKNV KDEMKLFFFG DHLVNNSEEI VLTEGEIDAM TVNQETNYAA ISLPNGSKSL
PIYLLPYLER FKKIHLWLDF DKAGKSSVFN FVNKIGLGRT NVITDANVQY LDEQLFERKR
KNLLTKGGLL LPLTICNNSI GVAEQKQGTI KENMQSDQKN GHTEGMRDGK GPNTTVDPMS
GTNKSDFKIG EKEKNEGDSR KSPISRDTGN VKEEERGISA REESKVRTLH FVQNNIMYIP
NNIVVKDAND CLKYNIDVRF FIENSEKVKH SQILNFNDLR QNILEELKYP DRINGVKSKT
IPSLNKFLYG LRMGELSIWT GPTGVGKTTL LSQLSLDYCI QGVSTLWGSF EINNIKLGKV
MLNQFCGKNL EKNIDLFDLY ADKFELLPLK FLKFHGSTNI DQVLDAMDYA VYAYDVKHII
IDNLQFMLNI NKFSDIYELQ NIAIDKFRSF STNKNVHITL VVHPRKEDNN LLSIASVFGS
VKSTQEADNV FIIQRHVSKT NETVFFIDIK KNRFKGSLGR IPYLYNKENM TIKEMSISYL
NDAISGSSGY GTNGTTPSSN FVPKVGPLRD GLDFTLCDEY DYMKQLADEY ESKHAIRRYR
VGADGRVSGV GSGSANSPNT SSSHRAQNEC RNDIGSVDSW RNNQNKDNKS VNQVGGAEDE
PMNNNRIGST NMKSEKGNIK NILKGVDPGG TVTPVEKTPK SDKPSGDSIH LATPPNPNGE
KQEAPPDVSK QNVSSYRLSS EGIIKLCQEI KENESEKLKD KVITISMRDC VINNDSTIKD
IRNFIKTNKL NIKTAGKNLK KVDVFIAILQ SIPKEYITIN YVGEDVEMGD PDNNNVGSKS
GENVKQGTLN STLGVNHNKV SLGGSTSSAL PIRGSNKNDF NIVPTMQESS VNSRNIANSS
SGYVSDPRQG DVQSGEKQYS EEIKTLYGEE VTKRYIQDNI INVDDNIVNR IGTFKLEGDN
KMMSSVNLEY YEPVKKFDDD IESRFFLIHD KNYNEKINHI YKNVTHCGLD IETTGLEVFD
EKIRLIQIAV EDYPVIIYDM FNITKESVLS GLRQILRNGK VVKIIQNGKF DAKFLMHNNF
QVENIFDTYI ASKLLDKNKN MYGFKLNNIV EKYLNVTLDK QQQNSVWNNS LLNNNQLFYA
ARDSSCLLKL YKKLNSEICK ENMGTVNDIE NKCILPICDM ELNGITVDLD SLNKSTNEIL
SELNEETSKL KAELKDEEIN VNSQQQVLKA LQNNSVRDVS NKLIENTSDS NLKNFLNHKE
VVLLRNYRRL YKLYSAFYLK LPQHINKKTN KIHTTFNQLK TFSGRFSSEK PNLQQIPRQK
NIREIFIPQK NNIFIIADFK QIELKIAAEI TNDDIMLKAY NNNIDLHTLT ASIITKKAIA
DINKEDRHIA KAINFGLIYG MNYVNLKNYA NTYYNLNMSL DQCLYFYNSF FEHYKGIYRW
HNQIKQMRAL EYSTLSNRKV IFPYFSFTKA LNYPVQGTCA DILKLSLVEL YKNLKPINGK
IILCVHDEII IEVDKKYQED ALKILVESME NSASFFLKKV KCEVSVKIAQ NWGSKE
//
