ID A0A0D9QI77_PLAFR Unreviewed; 997 AA.
AC A0A0D9QI77;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=AK88_03584 {ECO:0000313|EMBL:KJP86770.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP86770.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP86770.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
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DR EMBL; KQ001686; KJP86770.1; -; Genomic_DNA.
DR RefSeq; XP_012336618.1; XM_012481195.1.
DR AlphaFoldDB; A0A0D9QI77; -.
DR EnsemblProtists; KJP86770; KJP86770; AK88_03584.
DR GeneID; 24268898; -.
DR VEuPathDB; PlasmoDB:AK88_03584; -.
DR OMA; IREQFFR; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 8..388
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 498..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 112332 MW; BC5E05E307C16960 CRC64;
MVVFHLDDLE VFFPYDYIYP EQYAYMRYLK KTLDSEGHCV LEMPTGTGKT VAIFSLITSY
QYKKNDEGKF IFCTRTVAEM EKSLIELKKV IQYRVDTVRR RADSSGAACA ATNSNADGSS
GCGGGGGGFA NLDVPPGDIV ALGISARRCM CVNERVLRKH ERERIDEECR KLTATFVREK
NYINQKINKM GSTHTDKDRI SDFILKNRQH IDVEDYFDVY NTTNSLEEYG ELGLCGYYEN
YKKEFVLDLV QPGVYTIEDL KVMCKGYKNV QNVNVPICPY FCAKKIIEVA KVVVLNYQYV
IDPKVSKSVF IGRDVNSRVH LYKNDIIVFD EAHNIDSVCL EALSVNIDRN ILNRATSNIK
KLLSKIETSK IVNEEKVRED CNRILQKLRE ERGMDLKAGA GSEVKAGAAS QVKAGAASNV
KKRKIEEGKN GASGEGGEVY FDEDLNLIFA GGANRSGVED GACRGDVNGG EKQEKGESLM
DGLAKLLGQS IGQLLPSRQE REQTEVGGLF PEGNKGALNS DANDNANDGD NDGGDDPTDL
HYSPLLLEDI IKNIVLPGNI RKSEHFLNLM RIVVMYLKKY VNIYEITSEG PLSFLYKFEK
ETKLDTCFFK FCFDRLKSIL NALQVVHVDD YSALNIVCNF CTLLGSYFQG FIIICEPYPE
ATGIYDPVIQ FACLDSSIAM KSVIKKYKSV ILTSGTITPL ELYPKLLNFK TVLTASFPMS
FDRNCVCPLI VTKSSDLVPL SSQFSLRSDI TVIKNYGMLL VEMCKTIPDG IVAYFPSYIY
MEEVISSWYE LGIIANILEY KLIFIETKDI VSTTIALHNF KRACDLGKGA VFLSICRGKI
AEGIDFDKHY GKCVILFGIP YQYTLSRILK SRLDFLKETY NIQENEFLTF DAMRQASQCV
GRIIRNKKDY GIMIFADIRY ARNDKKSKLP PWIIKCMDIS NVNLTVSTAV NISRKFLLNM
SQEYKETGQT KLSQELICNQ AKCWALVKSV LNMDHFI
//
