ID A0A0D9QJB4_PLAFR Unreviewed; 983 AA.
AC A0A0D9QJB4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=AK88_03181 {ECO:0000313|EMBL:KJP87135.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP87135.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP87135.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; KQ001679; KJP87135.1; -; Genomic_DNA.
DR RefSeq; XP_012336226.1; XM_012480803.1.
DR AlphaFoldDB; A0A0D9QJB4; -.
DR EnsemblProtists; KJP87135; KJP87135; AK88_03181.
DR GeneID; 24268495; -.
DR VEuPathDB; PlasmoDB:AK88_03181; -.
DR OMA; GHNKNED; -.
DR OrthoDB; 208346at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 156..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..482
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 484..913
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 70..77
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 983 AA; 114637 MW; C6AF1F15C7F83E5F CRC64;
MERGEVKRRK GGDDDTNEER LDPPNMRLNV MKDKSWNSES MFNSVLFSNL SKEQIKIVQV
PLNKNLCIIA CPGSGKTSTL TARIMRSIIE KKKSVVCITF TNYAANDLKE KITKKVNCLI
DLFSETDVKC KLFTDKNSKK KYDTGTKIHS KTKLKVLHTI MFIGTIHSFC RYLLVKYKGP
FKILTDFISS NVIKLAFNNF YACFLKGKSA QGAGENFFAS GKDTKDDHKG SFDFMNFFNI
LMKSFSKRDA QQIEDEAEGQ ADEDGEGDDE DGDHYYNYLY HVQHENNRKD HFEHADIPTM
LKKKHILFLK KKIKLFKYVE LYRMKIEMNR VEARFYAEYK KILDGAKHIY YDFDDLLIET
YRLMKEDERV RDRILAEWHY VFCDEFQDIN TTQFNILRFF ANETCGRREE ERGAPHNANT
SNGANQEPHP YRAHESDRSL TVIGDDDQSI YSFRGAHINV FEKIIKEQNC LLFKLGTNFR
STKEIVRVSY NLILHNACCR IEKELRTNNV QGEKVNFHAL KTNNDQVSFI LCQIIFLKKK
YSYKFGDFVI LSRTNKTLKE TLKCINSVDV RRRAVKFFHE LGKGAKSGAS GVVKSEESDG
ALGGDHHWTD VTPDTFKIPI KEMNRKKSFF GAKEIVELIT VLRFLLNVDD DIILKKAFKI
IKNDKAVQGI LDKLESSDLG DTSQEGEVSS SAEGGNGLSL FNRIEKITRW YILWKRNQLN
TDEVQHLDVF TEEEIKIILD FFFCVNYFIK FASQPKSVYS LVMDMFRKTN FVNRILKRVK
RRREPEVMQG DKQNERQKNE RHEGEEEQSQ QRKKRAFKEC TSESDTNHPE LVNELKIKRD
LHTYFGISDE DLEEHELQNI FILLEMIMQY TPNQINKKCS DCLISFLNDF KNDIHEKMLV
EKVTLTTIHK SKGLEWKVVF IVNAMEGEIP QAAENNRDII EERKIFYVGI TRAKFFLYLL
CFLQNNHTGE KNTVSRFVSQ MAI
//
