ID A0A0D9QLS8_PLAFR Unreviewed; 2588 AA.
AC A0A0D9QLS8;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|SMART:SM00181};
GN ORFNames=AK88_02507 {ECO:0000313|EMBL:KJP87903.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP87903.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP87903.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ001668; KJP87903.1; -; Genomic_DNA.
DR RefSeq; XP_012335555.1; XM_012480132.1.
DR EnsemblProtists; KJP87903; KJP87903; AK88_02507.
DR GeneID; 24267821; -.
DR VEuPathDB; PlasmoDB:AK88_02507; -.
DR OMA; VICADGM; -.
DR OrthoDB; 227622at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 5.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR11319; G PROTEIN-COUPLED RECEPTOR-RELATED; 1.
DR PANTHER; PTHR11319:SF35; OUTER MEMBRANE PROTEIN PMPC-RELATED; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR SMART; SM00181; EGF; 5.
DR SMART; SM01411; Ephrin_rec_like; 10.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1769..1791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1803..1822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1870..1897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1960..1977
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2020..2043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2078..2096
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2103..2120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2140..2157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2164..2189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2258..2279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1062..1118
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 1119..1175
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 1254..1305
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 1610..1659
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 1720..1760
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 2543..2588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2483..2510
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2552..2567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2573..2588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2588 AA; 299770 MW; 875CB41024124C43 CRC64;
MRKKYEQSVH AHVANDQNEA SFFGKGSGLK FHELELAAHR CMQNKIVKRV SSSVPLLGVL
KNDFLNFVYK MSEAASNGKP GYGTEPKVAS PMKVNESNES SRSVTVKLGK LKFKRSPKNI
LKGKKRGINF VSLNLEKIIE LKHKDPLTLI SSIYSGKKEK FLSACYENEK IRNGNTCSRI
TTSEQICDVP VDFNLDYVFS YRDRNEHPSK CLVDNVPQYR IKNRDHVVVQ SGERFDLKIL
NESILLRTSV IITEGKCSDI IKSRSIHFEF EKSPNPFGDP ILHKGEVIGS EFKNINVKKE
AEGIFNVCSC YIDYLNNNYN SCLLASRHYT QIYTLRAIVP SHKIINVSTG EKININVKEY
ETLFPIQNAF IIEMVSGYHC NNINKKSFTQ VQQDFYQNMK RLNFYDVYLY QVGPNEIIED
VVFWKPGNYL LCYTSIERGT KFSALLATIH VTGYDLEEVN YLYVDLHSTK LQLGHSVFLK
NIGIGKLSEV VFKKKEAENC SGEVVFYSND TLEINIEKKE HIRIDVIHVS DIKLIEYNEL
LDICSGENGK YRLIGRAQSK PYILHTHENI FLSKELNFPP DDVRTYVMKK ESRFFKFYPY
LMEHMLHNKV DALYISFLCY SSKNEVRVTY SSDRNMTPKP FAQFRITQAS SSVLYVTNKE
IKLYVLKKNL QSLFVYDITP NNVRRRRRTT GRYVDDPHMY SLLTFYFDYA NFVKCENCST
PILMEPVYDE NRILKLLFLV TSDPLRRIII VNLKLDSVYT HNSNDVKKQF EQIGEFKFSL
DVLKDSSYLI THVSCGMLKN KSFDCFLIDQ MNNSVIAVHY MEQRNKLLLM DTFQGESNAN
DENAYLYNFV FSQSDTYLQN PKHVVPFPYG DSYVLFVDED ETTQMNIILY DRNKPSKRFS
YVTKINSTYI DEGKINKIYK FYDHKELINR NVLLIVKELE KSVHFVMGPI QNITNVTELK
YSYPSIIQDN GIPYALKIKS DEIKKMNLLH NFQIDVHNVN KAHHVTIHKH DGTITIKLSE
FIDDPVNLTA KMYGVFMELN TNIQFTVICA DGMKALNGRC VACPLGSYNN IHEYRKHENM
HECIKCQENS ITKNEASTSI AHCLCLPGYE LNNNDECVPC AMGTWKSETS NTPCIFHCYP
NSQSLIRGSR SEEESECKCL KGYYFVSKDG INFCEQCDIG HFCPGGYRGA KKKCPGNTTN
AELENFSIKS CKCDAGFEPF DSSNLNNYDF MANPIFDDYK DFEQEMEPSQ VCVPCKIGSY
KNTVSEQKCK SCSAHVYTDA IQSTSIAECK KCENGYYLHA QDLCLLCPDN HYCPGYPAQD
KKYAFYENQK VPCDDKTLTK PPNELNVSRL NCLCKKGFEY AKSEENEFAC LEVPKNYYKS
ELSNTQKKPC PENSVTSYTK TKSRIKCICV GGYYWDINEN KCIKCPKGYY CPGGHLKDCF
LKNTLHLCKP KKIKCPIKNT TTKAEESFSE SSCLCDKGYT LSKEALRECV LCPVNTYKDF
VSNAECTMCL TPYTTDGQVG SAKEEDCTCS GGYYFFNHCI PCSDKNTYCK GGKMIVNNKS
KTIHYGPSKC PPNTVVSFET ERPHNQSFCV CKKGYKHVYT ASNYTKICAP CGRGFFKTMI
GDFSCESKCK PNSTSLTGTT HETHCSCLRN YYFKNGICVN CPDGAYCEGG FEEETLLSLK
KGVNSLDPSK IKHVMPVPKE NYALYKLKGN IYNTDWFIVE CPIKEACLYN EKCHESMTNF
LCGECKKGYT NNFSKLNLCI ECSGNIMNIL HIIFVSIFVL LFTVIMAYLN VFTGANRKSV
HSIVIKIALN YFSCMKIFYV MGTSELYFPL NFSSHVNYII QSIKTLLKAK KNYGPYCILT
TYFKFSHSDA YYYGMLFYAL RPILLAITLT ILMYVVVEIY KFKMRDQTRI KLNVVDKIKE
LGKTKLYEEI MQELPSERGL VLFRYIPIPG DSKFKRIKKF LEDMIPMYVT LLFFIHTKTT
YSMLTLLDCK AIYYNDKFVE QYMSYAPSVK CDMSGDYAKF FLLGIIGIAV WGIGIPLMSY
LVLYKNRKHL HSENILFKYG FLNNGFNFQF WYWESIVFFR KILILLISSV PVFKTARIFG
TTMWLFTVIS FFFLTVQIIL QPFDSRNYHI LNKLETYSMF AWTITLMTFV FLTVSSADAT
INFYVLLFLL FFNFIFVAKV LIALCYSYIE NLRHIKKHVK IPFLNNFFEK MAKIAEEKYY
KEPIVSLNTR DNSIQFMRKY RRYPLRKHRL LTNEEKNYFL NVLSNFIYFG VSNLNFTIFH
SHFMEFMLRL SVIDNEMLHK RGKRGILKLI AKDPQNIDEW IKIKESELNK STFFERHKKI
LNLFTKNMLI IQNNIKSIIY QGDKHTIISD YEVLINVLKY DEDFITDFKF LYDEDAVKSG
LTLSDLQLSF TKIKMKDKGL IMQLFSLFIA KKNIVQFERD VHLKNKIEQL KTLYDILITA
NEKKKITFRK NFEDAVKADP FDYRTLQNEL ETLNERINNL IDNYQKLKDA NYYQDECDYN
NNAALNNNSE FFDNNLKELS FKEETNDEQN IGNAEEGDNI IQNEDTNEDN VGNEDGKEEN
KMKEQKRS
//
