ID A0A0D9QLT7_PLAFR Unreviewed; 1228 AA.
AC A0A0D9QLT7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=ATP-dependent helicase HrpA {ECO:0008006|Google:ProtNLM};
GN ORFNames=AK88_03678 {ECO:0000313|EMBL:KJP86671.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP86671.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP86671.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ001688; KJP86671.1; -; Genomic_DNA.
DR RefSeq; XP_012336711.1; XM_012481288.1.
DR AlphaFoldDB; A0A0D9QLT7; -.
DR EnsemblProtists; KJP86671; KJP86671; AK88_03678.
DR GeneID; 24268992; -.
DR VEuPathDB; PlasmoDB:AK88_03678; -.
DR OMA; DPMVAPE; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 254..329
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 579..742
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 765..941
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 74..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..195
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1228 AA; 141038 MW; 2C052777F0B34B53 CRC64;
MECLSKINLI QKVNAELYKS LGVEDDNLAE YLIYLCKKAK SLEEFCKDVF ENGGEIEQSV
LKYLYDIIKR PGGDSAGKAS GGKETRTDDD EQEEEDGVDK ENRLEVKMIE KKNEKMKGFH
CLAIKNDEQL TRLSDGSGVE AGSDTATGSR GARPGKRSHH RDRSHSQDGS HTRDGGRHAH
RDRDRHRHRG RSHSREGDRH VRDGDHHRDR DRHRDRDRHG ERRRDRSRSR SRSRDGDHKR
RRREGVDSRA LRVNNIFTAT VSKIMDFGMF VSFRTIPEGY KEGLVHCTDI LPNRKRVTNM
NEKFQKGMKV KVKVQAIFGE KIHLNMSEVD QKTGQNLVSD DEDDGDEGSA NRKGKEKDKN
DMSIFDDLHE DYKELKKHNS DVFKEDPKDT IKYESVIKMQ SDYSKWEIQQ LIKSGIMHDE
QIKQEYKNLR NDEKIEDEEE IIEIEVNERE PAFLKGQTTK AGAKLSPIQV IVNAEGSLAR
AITTTSALAK ERKEQKQNEQ NAIYDSIPKD ISRPWEDPKP ELGERTIAEA LKNIGKNYDL
PEWRKNYLHN NISIGVKNPM PVNEQREKLP IYNLKKDLMK AIAKNNVLIV IGETGSGKTT
QIPQYLHEAN YTDKGIVGCT QPRRVAAMSI AKRVSEEFGC ILGQEVGYSI RFDDCTSNDT
IIKYLTDGML LRETLSDTML SKYSFIILDE AHERTISTDI LFCLLKDVVK RRPDFKLIVT
SATLDAEKFS TYFFNSPIFT IPGKIFPVEI LHSKEPESDY VEACLITVLN IHLNEHPGDI
LVFLTGQDEI NTACEILHER MKKLESMSPP PLIILPIYSS LPSEMQSVIF DPAPQGCRKC
VLATNIAEAS LTIDGIFFVI DPGFCKIRKY DSKRDMDSLV VAPISKANAK QRAGRAGRTG
PGKCYRLYTE EAYKNEMAET SIPEIQRINL GSTVLLLKAL GVNDFLHFDF MDSPSVDTLI
HSLENLYYLG ALDDNGYLTK LGKKMSNFPM EPNLSKILLT SINFNCADDV VTIVSMLSVQ
NIFYRPQNKA LLADKKKNKF IMPQGDLITY LNIYNRWREN NYSNYWCHEN FIQSRALKRS
QDVRKQILSI FERYNYEVEK NRSRNDSAKY VSICKSICSG YFNHVCKRDA QQGYNTLLTN
QQVFIHPSST LFNKNPLFVV YHELVLTNKE YIRDCTIIQP QWLIQLAPNL FIPADEKKIS
KIKLREKIEP LHNYYEEPNA WRLSRRKG
//