ID A0A0D9QR10_PLAFR Unreviewed; 3611 AA.
AC A0A0D9QR10;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=USP domain-containing protein {ECO:0000259|PROSITE:PS50235};
GN ORFNames=AK88_01090 {ECO:0000313|EMBL:KJP89212.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP89212.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP89212.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ001653; KJP89212.1; -; Genomic_DNA.
DR RefSeq; XP_012334151.1; XM_012478728.1.
DR EnsemblProtists; KJP89212; KJP89212; AK88_01090.
DR GeneID; 24266404; -.
DR VEuPathDB; PlasmoDB:AK88_01090; -.
DR OMA; GYKECKT; -.
DR OrthoDB; 227085at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF957; USP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
FT DOMAIN 3231..3601
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 144..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 956..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1533..1563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1594..1647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1775..1823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..2029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2178..2218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2487..2518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2610..2632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2952..3042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3084..3136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..275
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..702
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..871
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..898
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1055
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1273..1301
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1335..1359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1549..1563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1775..1816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1899..1916
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1939..1969
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1981..2000
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2001..2022
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2495..2509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2611..2632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2978..3000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3011..3033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3084..3111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3112..3136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3611 AA; 408643 MW; DA2FF87C15A51D59 CRC64;
MKLKRDKPLL NDDMDDGDLF NPILLRHFIN ERKAKRVSTC STLNRKKNEH HHKYNSSYFG
GGTHPCNGGD AFDEWGGDTH EYDDAVFPIV HKLKTNAKQG CTLKRECENG KKNCRKEDTL
FFPAQFAPTD DKNFLPRKAV KRGDFQKSVH PVRDPSRRQE RTRRKVKEAT KQNNPLWGDD
ACLLCGKCRK DRREDGALWP DQHNHGWHQT NGYHDELYIS DMYSCDGDFL DADTENAEGV
KAPSMEEWGD PSKPHKSRKV GKGRQMSKIR QMSKIRKSRT RDNCKNCLMG CRSGSVTTTQ
SSSSHHDRYQ EEEEKGGKAK KKKKKKKKKS HMNSMEEVPN HVASLFFYLS DMRKNVLSKA
DDDVPVKKSC NHFCKGERTR GAEGRRGGSR GGRRSDRRSD RRSGQFDGAS SPLDCKNGST
EKNGAARASD EFSSENWAKN WGTNSAKNSA KSNAKSNAKN SAKNSAKSNA KNSAKNSAKN
SAKKEDGDAD ESGDENEKEK EKEKEDADGD EGEDENQVVG ESQRQRQKQE KKKKSRKNGN
GKEDTVETND HSGNCSSREA GTKNYTQGKR TGTLHDDSRA PVPEWDFVRN GRGDEASGKS
AREKHRRSHR SGDSGCKRSN RDRRSRRDEG PLLGETIFLS NEIEGEKFPS VSQNHNARVV
AKSKKVTIRS GNHIESEVSR APPNDRVDRD AHFTKKISRQ SHPAGERTMN NNSYSLPDAE
DFEEESHHPQ KEFEQRGKKN KKKNSKENDM DGSLPERECV AEGDQRGHPP SSPHEKEAER
STSKYTHIIA SSPQKKKKNS SEINDEASVH DEKKTSVKDN VYENFIREYQ NLQSLFSFNK
DKMEDARGKD DDEDDDDEEE EEEEEEEEEE EGEKKKENKN RDGPFGGSRS RVLDRDVNEN
VRKDFSLKNH LNTMLTTDGY TNTKGHVPPR DANAGDKGVE SLEQLSYSFN QYNNTESMDK
VQVRDVPAKD SVRSRGKGVG ANDDTDSTGV VPIGDNQQEK THSTGKEKGS GINEAVTHAH
DVEKNKKGQK SVPDVDASEG GGDGKKKHTE GSNKHVRQES SGGSVQRMKQ IGYAEGAAKE
KSDLLVWNDM VKGADLMTRG DMVKGGDLVK GGDLVKRGDL MQRGDLLALG DSFVKPTLFS
NKTVQNEKDY FEYEANNSKK LLHKNMSNMY SMNGSNLTFN QDFFKDMLLL NDEKKKEKKK
KKSTRQHSTF DQFHELSYFA DVKNAKHSKH RNNSAHQEDE LTKSYSFKRD KWGDRKSSSA
GKSITGASQS FKEEEENEEE EEGDEDEDDD EGEEEEEEEE DDQVGRGRKG TGGEDVDKEE
SDEYGDYDEG GGAEGGGDSF DHEDLHNGDH MEKTQGASGS HKERKKKKKL QGELAKKSKS
GKLEKVKIVE EKNKLHKRRS TRDHKRNGSR TQNNSICSLE DDDFCDDNAG DFPYHNRRGR
HRDGVMGDDP LAENIYMDML HDLRGVNLHK GILAYPDEVQ NHDEGVNAEK AKRKRKTSRR
KKEELREEYM KEFFGSVLDN QMYKKSLNGK DFSHHFTQQG EEDGEEEGQE ERNDRHHRDA
REKRMLRNIS KAIRAENINT EIELLRNEIL QKKTSKESLP SGEKKKGTHK SGTPVDITHR
KKKSHDKEEE KRTSFKRGSR GDSTVDYKGD YKADAKTGRH ASHQNTFHST HAKDEEDYYT
FHHEKKKRES HVKVKDVNFE EDERFKKCKS RSRVGARDRV HSFYDEASGV PPAHRNNSSS
GGLAVGGLHL NKSLEFFSNN FLSLKRLIER KNADTNYDPK REDDYVEKAE EEAEFDSKKK
KKNSYDEYEH SHMTNNKTAS HKTSRGLRFD NFFGLNKRNS DSLNFYPSSI KEDGKSGKGD
HRKKGARGRK DSGERFDSGF GAWFGTGFGA GFGSDSGGEN RRAARRARRG DGAGDGAADD
AEEADSVGNA SGADDMQDGK GAVDGERGHY TDDPAEGARR RRGEEKTLSA GRASDVVTDR
AGGRSSKDAP RDKAKKDATQ GQSGEGHQTE EQVQNEEQMQ SAEHQLWGPG KSYKNVKNIL
LSLELSNEDK IYKVRKILYY SSSDEKKLMI NEILNTLYVY PQLYVACIIC LFYLFILDNE
LFERNFNSED LVYLFNDKVD FRYAEWFLKT YIFYKFKFSS GTHSSEYYKN CVKSAVGSDG
KRGSIDVEEG ECSVEAARAS KGETAHGDET AAEVADKAAT DKASDRASDR VSDRVSDKVN
GSVREGNIKD KMFDVFFEGY HSSVDSSDNC FCERKRHMVR AEKGDANDLW KSIDKLKCVG
YKECKTLLKL CLKNEKQKNI NHLKASKIRS LVISIWSNIY TSRPKKSFLK IIFNWLNSRT
DDLNKKKNLL YLLQAEKKKN VHLQKICFTY FLKHIIKYKE ECSNDLIYSL YLIEENELKK
YSREFVEMNK IDVNQFISIW NVMCILFWDT KKINDFAFLH KSKFYYYDFM LIFFRAFYEY
ACVNKGMERG ALYLKKTVPA EGVAATPGAE TTDAAPPPRS TSLSNCSSNK DDTQEDEGDG
YLNLFDLENI INNFNFDDFV SNEMRSNSYF DAFLGGGPSA RRPGTGEANI AARPKLNCSV
VGSLPLSTLQ SMGTNEVCPT EPFLQTDKPV EAASQGGSPQ PPTFAPNTQR NAYPNDNSEM
ENILLLGICI KIVICRISNL LNAKSCLEQF NYFLNNHKLG FRTFKNANMV LVYFIPFFKR
YFFLWKFIEH EIDVEIMTLL QNILNDLEQI QASSPMGRAF LPGVTTTHQL WGMSNPPRVG
DMTHGRNLHD RCPQESLPER FQPPFGDRPY MRSSTCNSQN RGVIPPGTDK KINSLEHFYA
NGKFNLYSDR KQTMGRSGFN GDRTQEDDAF FASGGRGRGD RILQSNGHHH TYNDNHHMGN
TALMSVTPIK ATLCRSEDDT DENCITYDDM FKNYDSENNS EGRASLDENC NVKEYITSLH
FNNPLEEKIL SRKKGSTSLG GQEEDATHGD NMEEENSQSK EAGGTVGETS GSTCPQDSKE
ELFGSNPMRV GNFPMDSSIS RQNSSSQNYH MNKEHKNGGM KDLLHGKKSS EGGNVTAMMM
QSDPFASENN VMKKFPSLGV LESEDEKAEK GLHVSNENRK RERKKESMKN NATATRDVND
PNGVANQTEQ IGTHSMNGPI NEFPYENPMQ NNMPPSASTS TLSRNICIKN NPLNENYQEV
DFTTSSLRRK IKSKRGQGEG GGGGAPKYLM LKVDTCELNK MTQSKLKFPP VGLVNLGNTC
YLNSLLQALY STVSFVVNLY LFNIRGDSKE GGMEHNSNPF AEKEMSTAVL NGTNAQKGAM
QNGLSTMDGV NNVNNSVGKM NTLTRLNTLY GTTPMNHVFL AESEKFLQEL KNFYIIMTTT
QKTCVSPDSI LGLLPHELNN RHQQDVTELL RYIFDRLGGS SKEFLRLIFS GVLVQKVQCQ
KCFFVSKKEE VIHDLSFPVP VKASEKLSIQ KFFDTFVKKE KIHGSNKYRC SKCNKRRNAL
KWNEIISPPC HLILILNRYN WSFSSNEKKK VKTHVKVNSK IVVNNFDYKL YGSIIHGGSS
ASSGHYYFIG KKSERDPEDN KNDWYQINDS VITKTSSKSI NKISKDPSND HTPYVLFYRC
KQAPPSPALH F
//
